University of New England

Markus Frederich, Ph.D.

Assistant Professor of Biological Sciences
(207) 602-2406
mfrederich@une.edu

Website

Education

M.S. – Biology, 1996
           Technical University of Darmstadt, Germany  

Ph.D. – Alfred-Wegener-Institute for Polar and Marine Research, 1999 
            University of Bremen, Germany

Postdoc – Cardiovascular Physiology
                 Harvard Medical School / Brigham and Women’s Hospital

Courses

BIO245 Principles of Human Anatomy, Physiology and Pathophysiology I 

BIO280 Honors Biology

BIO303 Seminar in Molecular, Cellular and Systematic Physiology

BIO322 Comparative Animal Physiology
  
BIO345 Principles of Human Anatomy, Physiology and Pathophysiology II

BIO480 Muscle Physiology

Research Interests 

Temperature physiology of marine invertebrates 
    
Energy metabolism of animals under stress  
    
Influence of AMP-activated-protein-kinase (AMPK) on energy metebolism and temperature tolerance in marine invertebrates

Selected Publications

Frederich M, O'Rourke M, Towle D (2006) Is AMP activated protein kinase expression in Cancer irroratus a better signal for temperature stress than HSP70? The MDIBL Bulletin 45: 37-39.

Zhang L, He H, Frederich M, Balschi JA (2005) The relationship between 5-aminoimidazole-4-carboxamide-ribotide and AMP activated protein kinase activity in the perfused mouse heart, American Journal of Physiology 290: 1235-1243.

Frederich M, Zhang L, Balschi JA (2005) Hypoxia and AMP independently alter AMP-activated protein kinase activity in heart, American Journal of Physiology 288: H2412-H2421.

Pinz I, Perry D, Frederich M (2005) Activation of 5’-AMP activated protein kinase during anaerobiosis in the rock crab, Cancer irroratus. The MDIBL Bulletin 44: 31-32.

Frederich M, Balschi JA (2002) The relationship between AMP-activated protein kinase activity and AMP concentration in the isolated perfused rat heart, Journal of Biological Chemistry 277(3): 1928-1932. 

Bock C, Frederich M, Wittig RM, Pörtner HO (2001) Simultaneous observation of haemolymph flow and ventilation in marine spider crabs at different temperatures: a flow weighted MRI study, Magnetic Resonance Imaging 19: 1113-1124.    

Frederich M, Sartoris FJ, Arntz WE, Pörtner HO (2000) Haemolymph Mg2+ regulation in decapod crustaceans: physiological correlates and ecological consequences in polar areas, Journal of Experimental Biology 203: 1383-1393. 
    
Frederich M, Pörtner HO (2000) Oxygen limitation of thermal tolerance defined by cardiac and ventilatory performance in spider crab Maja squinado, American Journal of Physiology 279: R1531-R1538.

Grants and Awards 

Fast and slow cellular response to thermal stress: The role of AMP activated protein kinase and HSP70 in two decapod crustacean species (2007) National Science Foundation, $377,000, 3 years.

Temperature dependence of AMPK gene expression in marine decapod crustaceans (2005) American Physiological Society Research Career Enhancement Award $3000, 1 year.

Temperature dependence of AMPK gene expression in marine decapod crustaceans (2005) New Investigator Award from the Maren Foundation at the Mount Desert Island Biological Laboratory, Salisbury Cove, ME, $6000, 1 year.

Characterization of the role of AMP-activated protein kinase in temperature adaptation of marine invertebates (2004)  New Investigator Award from the Maren Foundation at the Mount Desert Island Biological Laboratory, Salisbury Cove, ME, $5500, 1 year.