Neuropharmacology of Serotonin: David Mokler, Ph.D., and Peter Morgane, Ph.D.

Research Interests

mokler
Dr. David Mokler
The Neuropharmacology Laboratory is involved with projects investigating the basic principles of the serotonin system in the brain, focusing on behavior and chemistry. We are investigating the effects of hallucinogenic drugs such as MDMA (ecstasy) and LSD on the brain. MDMA is a known neurotoxiciant, and produces long-lasting changes in serotonergic and dopaminergic neurotransmitter systems and behavior. We are also assessing the effects of chronic abuse of morphine on the neurochemistry of the brain using a model of drug craving. Laboratory website

Current Laboratory Positions and Professional Training Opportunities

The work is done in a collaborative fashion between Dr. David Mokler and Dr. Peter Morgane of the Department of Pharmacology at the University of New England and the Center for Behavioral Development and Mental Retardation at the Boston University School of Medicine. Undergraduate science majors at the university of new England are actively involved in the research.

Research Grants

• Dr. Mokler and Dr. Morgane are co-investigators on a Program Project Grant on Prenatal Malnutrition in the Center for Behavioral Development and Mental Retardation at the Boston University School of Medicine - Total direct costs - 1999-2004 - $5,000,000.

Recent Publications

• Johnson, D.W., Eodice, P., Winterbottom, H. and Mokler, D.J. Increases in extracellular dopamine release in the nucleus accumbens after acute cocaine are not required for expression of behavioral sensitization in female Sprague-Dawley rats. Pharmacology, Biochemistry and Behavior 65 (4): 659-664, 2000.
   
• Mokler, D.J., Galler, J.R. and Luebke, J.I. Development and modulation of GABAA receptor-mediated neurotransmission in the CA1 region of prenatally protein malnourished rats. Nutritional Neuroscience 4: 109-119, 2001.
   
• Morgane, P.J., Mokler, D.J. and Galler, J.R. Malnutrition, central nervous system effects. Encyclopedia of Neuroscience, Elsevier Press, 2001.
   
• Morgane,P.J., Mokler, D.J. and Galler, J.R. Effects of prenatal protein malnutrition on the hippocampal formation. Neurosci. Biobehav. Rev. 26(4): 471-483, 2002.
   
• Mokler, D.J., Clayton, N.P., Field, S., Mastalong, H., Stadig, S., and Dixon, M. Discrimination of the 5-HT2 agonist DOI: Generalization to electrical stimulation of the dorsal raphé nucleus in rats. Pharmacology, Biochemistry and Behavior, in press, 2003.
   
• Mokler, D.J., Galler, J.R. and Morgane, P.J. Modulation of 5-HT release from the hippocampus of 30-day old rats exposed in utero to protein malnutrition. Brain Research, in press, 2003.
   
UNECOM Alumni Services
     

Back to Top

 
» Advanced Search