Analytics

Services

Pharmaceutics: Drug solubility, pKa, and stability studies; conventional and nanoparticle drug formulations; drug release by conventional and nanoparticulate formulation; drug metabolism and pharmacokinetics.

Inorganic: Determination of metals and other inorganic components released by implanted medical devices; toxic inorganic substances in tissues, physiological fluids or blood spots; inorganic components bound to proteins; or small drug monitoring, including determination of therapeutic and illicit drug substances in physiological fluids or blood spots and drug substances and drug metabolites in environmental samples.

Biomarkers: Peptides in urine or other physiological fluids; cholesterol and other intermediates or products of the isoprenoid pathway; homocysteine and other amino acids or their catabolites; thiamine and other vitamins or their metabolites; carnitine esters; proteomics; lipidomics; and metabolomics. 

Instrumentation

  • High-sensitivity LC-MS/MS (Agilent 6460 equipped with 1200 series RRLC)
  • Medium sensitivity LC-MS/MS (two Micromass Quattro LC triple Quadrupole mass spectrometers equipped with Waters Alliance separation modules and UV detectors)
  • High sensitivity GC-MS/MS (Agilent 7000)
  • Two ICP-MS (Agilent 7500 series and Varian 820-MS inductively coupled plasma-mass spectrometer)
  • Q-TOF MS (Micromass Q-TOF Micro hybrid mass spectrometer interfaced with a Waters Alliance separation module)
  • GC x GC-TOF (Agilent two-dimensional GC system with SAI Kronus TOF-MS), MALDI TOF-TOF (SAI Laser TOF TT)
  • Olis DSM 20 CD
  • Olis DM 45  Spectrofluorometer
  • UV-VIS Spectrophotometer
  • Horiba Dynamic Light Scattering Particle Size Analyzer LB-500
  • Beckman Coulter Multisizer 4 Coulter Counter