Amy M. Deveau, Ph.D., Chemistry
Associate Professor
adeveau@une.edu

Expertise

Small molecule design, synthesis, & spectroscopic characterization; synthesis of biologically active, nitrogen-containing heterocycles with applications to chemotherapy and pain; the design and synthesis of exotic amino acids; total synthesis of natural products; design and semi-synthesis of novel opioids; molecular modeling.

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Education

Ph.D., Chemistry (organic & medicinal chemistry), University of Virginia, 2003

B.S., Chemistry & Secondary Education, Stonehill College, 1996

Post-Grad Training

Post-Doctoral Training
Chemistry Department (synthetic organic), University of Vermont, Burlington, Vermont

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Research and Scholarship

Research Interests

My research interests lie at the juxtaposition of chemistry and biology, specifically in the area of medicinal chemistry.  My main area of expertise is the synthesis of biologically interesting heterocycles that contain nitrogen (i.e. amino acids, opioids, etc).

Current Research or Scholarship

I presently have three ongoing research projects in my laboratory: (1) the design and semisynthesis of novel opioid derivatives for the treatment of pain and addiction;  (2) the design and synthesis of novel DNA intercalators;  (3) the development of greener methods for organic synthesis and their pedagogical application.

Selected Publications

Andrea L. Pelotte, Ryan M. Smith, Mario Ayestas, Christina M. Dersch, Edward J. Bilsky, Richard B. Rothman, Amy M. Deveau. Design, Synthesis, and Characterization of 6β-Naltrexol Analogs, and Their Selectivity for In Vitro Opioid Receptor Subtypes. Bioorganic & Medicinal Chemistry Letters, 2009, 19, 2811-2814.

Amy M. Deveau, Nancy E. Costa, Elizabeth M. Joshi, Timothy L. Macdonald. Synthesis of Carboline Homodimers, and Evaluation in In Vitro Carcinoma Lines. Bioorganic and Medicinal Chemistry Letters 2008, 18, 12, 3522-3525.

H.D. Jain, C. Zhang, S. Zhou, H. Zhou, J. Ma, X. Liu, X. Liao, Amy M. Deveau, Christine M. Dieckhaus, Michael A. Johnson, Kirsten S. Smith, Timothy L. Macdonald, H. Kakeya, H. Osada and James M. Cook. Synthesis and structure–activity relationship studies on tryprostatin A, a potent inhibitor of breast cancer resistance protein. Bioorganic & Medicinal Chemistry 2008, 16, 4626-4651.

Student Opportunities: Yes