October 03, 2017
Ada Olins, Ph.D., and Don Olins, Ph.D., both research professors in the College of Pharmacy, discussed their discovery of nucleosomes with ‘Active Motif’s Podcast,’ a program dedicated to epigenetics research.
The nucleosome is the fundamental first-level folding of nuclear DNA. It is vital to higher levels of chromatin packaging, highly conserved in evolution and is the site of chemical modifications that possess genetic regulatory functions. Since their discovery in 1974, the Olinses have focused their research on nuclear function and architecture, as well as chromatin structure.
The Olinses’ interview coincided with the annual EMBO conference in Heidelberg, Germany, which promotes excellence in the life sciences. This year’s conference celebrated the 20th anniversary of the publication of the crystal structure of the nucleosome. During the event, the Olinses presented their current research on "Epichromatin" (nucleosomes at the surface of chromatin and chromosomes).
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