Amy J. Davidoff



University of Rhode Island



University of Rhode Island



Colby College


Post-Doctoral Training


Brigham and Women's Hospital, Harvard Medical School



Post-Doctoral Training


Graduate Hospital and University of Pennsylvania School of Medicine




Diabetes and obesity




Cardiovascular disease


Current Research

Evaluating the pathogenesis of heart failure associated with diabetes; assessing the cellular consequences of elevated sugar and fats on isolated heart muscle cells, primarily focusing on excitation-contraction coupling and insulin signaling; studying interventions which can prevent or reverse heart disease associated with diabetes.

Research Interests

cellular mechanisms contributing to development of diabetic cardiomyopathy

Selected Publications

Seminal Research publications:

Davidoff AJ, Rodgers RL (1990)  Insulin, thyroid hormone and heart function of diabetic spontaneously hypertensive rat.  Hypertension  15:633‑642.

Ren J, Davidoff AJ (1997)  Diabetes rapidly induces contractile dysfunction in isolated ventricular myocytes.  Am J Physiol  272:H148-H158.

Davidoff AJ, Ren J (1997)  Low insulin and high glucose induce abnormal relaxation in cultured adult rat ventricular myocytes.  Am J Physiol  272:H159-H167.

Ren J, Gintant GA, Miller RE, Davidoff AJ (1997)  High extracellular glucose impairs cardiac E-C coupling in a glycosylation-dependent manner.  Am J Physiol  273:H2876-H2883.

Dutta K, Carmody MW, Cala SE, Davidoff AJ (2002)  Depressed PKA activity contributes to impaired SERCA function and is linked to the pathogenesis of glucose-induced cardiomyopathy. J Mol Cell Cardiol 34:985-996.

Davidoff AJ, Mason MM, Davidson MB, Carmody MW, Hintz K, Wold LE, Podolin DA, Ren J (2004)  Sucrose-induced cardiomyocyte dysfunction is both preventable and reversible with clinically relevant treatments.  Am J Physiol Endo and Metab 286:E718-E724.

Schwanke ML, Dutta K, Podolin DA, Davidoff AJ. (2006)  Cardiomyocyte dysfunction in insulin resistant rats: a female advantage.  Diabetologia  49:1097-1105.

Fülöp N, Mason MM, Dutta K, Want P, Davidoff AJ, Marchase RB, Chatham JC. (2007)  The impact of type-2 diabetes and aging on cardiomyocyte function and O-linked N-acetylglucosamine levels in the heart.  Am J Physiol Cell Physiol 292:C1370-1378.

Lebeche D, Davidoff AJ, Hajjar R. (2008)  Interplay between impaired calcium regulation and insulin signaling abnormalities in diabetic cardiomyopathy.  Nature - Clin Pract Cardiovasc Med, 5:715-724.  PMID: 18813212

Marsh SA, Davidoff AJ. (2012)  Heart Smart Insulin-Like Growth Factor 1. Hypertension 59(3):550-551, Epub 2012 Jan 23, PMID: 22275529.

Funded Grants

2000-2004 National Institutes of Health/National Heart Lung and Blood Institute, R01 (PI)
2001 American Physiological Society Summer Research Program for Teachers (Sponsor)
2004-2007 American Diabetes Association Research Award (PI)
2006-2007 Diabetes Education and Research Foundation (PI)
2011 Diabetes Australia Research Trust (Co-PI)

Invited Plenary Presentation

2011 Pathogenesis of abnormal myocardial E-C coupling and impaired insulin signaling in diabetic hearts: A sweet new connection. Baker Heart and Diabetes Research Institute, Melbourne, AU

2012 The role of drugs and supplements: A focus on cardiovascular health drug-drug interactions. York County Senior College, ME

Amy J. Davidoff, Ph.D.

Amy J. Davidoff



Professor of Pharmacology

Director, Histology and Imaging Core Facility

Biddeford Campus

Pickus Center

(207) 602-2824

On Campus