University of Rhode Island
University of Rhode Island
Brigham and Women's Hospital, Harvard Medical School
Graduate Hospital and University of Pennsylvania School of Medicine
Diabetes and obesity
Evaluating the pathogenesis of heart failure associated with diabetes; assessing the cellular consequences of elevated sugar and fats on isolated heart muscle cells, primarily focusing on excitation-contraction coupling and insulin signaling; studying interventions which can prevent or reverse heart disease associated with diabetes.
cellular mechanisms contributing to development of diabetic cardiomyopathy
Seminal Research publications:
Davidoff AJ, Rodgers RL (1990) Insulin, thyroid hormone and heart function of diabetic spontaneously hypertensive rat. Hypertension 15:633‑642.
Ren J, Davidoff AJ (1997) Diabetes rapidly induces contractile dysfunction in isolated ventricular myocytes. Am J Physiol 272:H148-H158.
Davidoff AJ, Ren J (1997) Low insulin and high glucose induce abnormal relaxation in cultured adult rat ventricular myocytes. Am J Physiol 272:H159-H167.
Ren J, Gintant GA, Miller RE, Davidoff AJ (1997) High extracellular glucose impairs cardiac E-C coupling in a glycosylation-dependent manner. Am J Physiol 273:H2876-H2883.
Dutta K, Carmody MW, Cala SE, Davidoff AJ (2002) Depressed PKA activity contributes to impaired SERCA function and is linked to the pathogenesis of glucose-induced cardiomyopathy. J Mol Cell Cardiol 34:985-996.
Davidoff AJ, Mason MM, Davidson MB, Carmody MW, Hintz K, Wold LE, Podolin DA, Ren J (2004) Sucrose-induced cardiomyocyte dysfunction is both preventable and reversible with clinically relevant treatments. Am J Physiol Endo and Metab 286:E718-E724.
Schwanke ML, Dutta K, Podolin DA, Davidoff AJ. (2006) Cardiomyocyte dysfunction in insulin resistant rats: a female advantage. Diabetologia 49:1097-1105.
Fülöp N, Mason MM, Dutta K, Want P, Davidoff AJ, Marchase RB, Chatham JC. (2007) The impact of type-2 diabetes and aging on cardiomyocyte function and O-linked N-acetylglucosamine levels in the heart. Am J Physiol Cell Physiol 292:C1370-1378.
Lebeche D, Davidoff AJ, Hajjar R. (2008) Interplay between impaired calcium regulation and insulin signaling abnormalities in diabetic cardiomyopathy. Nature - Clin Pract Cardiovasc Med, 5:715-724. PMID: 18813212
Marsh SA, Davidoff AJ. (2012) Heart Smart Insulin-Like Growth Factor 1. Hypertension 59(3):550-551, Epub 2012 Jan 23, PMID: 22275529.
2000-2004 National Institutes of Health/National Heart Lung and Blood Institute, R01 (PI)
2001 American Physiological Society Summer Research Program for Teachers (Sponsor)
2004-2007 American Diabetes Association Research Award (PI)
2006-2007 Diabetes Education and Research Foundation (PI)
2011 Diabetes Australia Research Trust (Co-PI)
Invited Plenary Presentation
2011 Pathogenesis of abnormal myocardial E-C coupling and impaired insulin signaling in diabetic hearts: A sweet new connection. Baker Heart and Diabetes Research Institute, Melbourne, AU
2012 The role of drugs and supplements: A focus on cardiovascular health drug-drug interactions. York County Senior College, ME