Dr. Cássia Mizuno joined the UNE College of Pharmacy in February of 2011 as an Assistant Professor in the Pharmaceutical Sciences Department. Dr. Mizuno earned her B.S in Pharmacy and Biochemistry at the University of São Paulo, Brazil. In 2006, she received her Ph.D in Medicinal Chemistry from the University of Mississippi, followed by her postdoctoral training at the USDA-ARS, where she worked on the discovery of natural product-based anticancer agents and environmentally friendly pesticides.
University of Mississippi
University of Sao Paulo-Brazil
natural products chemistry
multi-step organic synthesis
Dr. Mizuno research interests include modification of natural products in the search of compounds with but not limited to anticancer, antimicrobial, anti-parasitic and analgesic activities
In vitro cytotoxicity study of ent-kaurenoic acid derivatives against human breast carcinoma cell line. Simão, M. R.; Carneiro, L.J.; dos Santos, R. A.; Bastos, J. K.; Veneziani, R. C. S.; Ambrósio, S. R’; Mizuno, C. S. Medicinal Chemistry Research. 2016, 25, 303-309.
Synthesis and biological evaluation of polyalthic acid derivatives for the treatment of neglected diseases. Mizuno, C. S.; Souza, A. B.; Tekwani, B. L.; Ambrósio, S. R.; Veneziani, R. C.S. Bioorganic and Medicinal Chemistry Letters. 2015, 25, 5529-553.
Copaifera langsdorffii Desf. (Fabaceae): Evaluation of the potential gastroprotective effect of extract and isolated compounds obtained from leaves. Lemos, M.; Mizuno, C. S.; Sousa, J.P.; Nanayakkara, D. N.; Andrade, S.F.; Bastos, J.K. Brazilian Journal of Pharmacognosy. 2015, 25, 238-245
Dias, S. J.; Li, K.; Rimando, A. M.; Dhar, S.; Mizuno, C, S.; Penman, A. D.; Levenson, A. S. Trimethoxy-Resveratrol and Piceatannol Administered Orally Suppress and Inhibit Tumor Formation and Growth in Prostate Cancer Xenografts. Prostate. 2013, 73, 1135-1146
Mizuno, C. S.; Chittiboyina, A. G.; Shah, F. H.; Patny, A.; Kurtz, T. W.; Pershadsingh, H. A.; Speth, R. C.; Karamyan, V. T.; Carvalho, P. B.; Avery, M. A. Design, Synthesis, and Docking Studies of Novel Benzimidazoles for the Treatment of Metabolic Syndrome. J. Med Chem. 2010, 53, 1076-1085.
Mizuno, C. S.; Rimando, A. M.; Duke, S. O. Phytotoxic Activity of Quinones and Resorcinolic Lipid Derivatives. J. Agric. Food. Chem. 2010, 58, 4353-4355
Mizuno, C. S.; Ma, G.; Khan, S.; Patny, A.; Avery, M. A.; Rimando, A. M. Design, synthesis, biological evaluation and docking studies of pterostilbene analogs inside PPAR_. Bioorg. Med. Chem. 2008, 16, 3800-3808
Chittiboyina, A. G.; Venkatraman, M.S.; Mizuno, C. S.; Desai, P. V.; Patny, A.; Benson, S. C.; Ho, C. I.; Kurtz, T. W.; Pershadsingh, H.A.; Avery, M. A. Design and Synthesis of the First Generation of Dithiolane Thiazolidinedione- and Phenylacetic Acid-
2013 UNE- mini grant
2013 Maine Technology Institute SG-5243
The Development and Commercialization of Novel TRPM8 Agonists for the Treatment of Dry Eye