David J. Mokler

Dr. Mokler joined the faculty at UNE in 1986.  He received his Bachelor of Science degree in Psychology from Michigan State University in 1974 and his dual Doctorate in Pharmacology/Toxicology and Neurosciences from Michigan State University in 1984.  He teaches in the College of Osteopathic Medicine, the Westbrook College of Health Professions and the College of Dental Medicine.  He has a passion for Intraprofessional Education at UNE, being one of the first faculty at UNE to attend the IPEC national conference.  

His research focuses on the limbic system of the brain.  He has published widely on the serotonergic system of the brain.  He has worked in the area of prenatal protein malnutrition effects on the brain since 1995.  Recent work has focused on interactions of dopamine, norepinephrine and serotonin in the prefrontal cortex on attention in rats. 

Education

B.S.

Michigan State University

1974

PhD

Michigan State University

1984

Post-Doctoral Training

Department of Pharmacology

Medical College of Virginia, Virginia Commonwealth University

Richmond

Virginia

Expertise

neuropharmacology

Psychopharmacology

substance abuse

drug abuse

brain development

dopamine

serotonin

animal behavior

limbic system

Research

Current Research

How does the adolescent prefrontal cortex differ from the adult prefrontal cortex?; Dietary influences on behavior and brain chemistry in adolescent animals; The effects of prenatal protein malnutrition on the adolescent and adult brain.

Research Interests

The effects of prenatal protein malnutrition on brain development

Selected Publications

 

Bove, G.M., Chapelle, S.L., Boyle, E., Mokler, D.J., Hartvigsen, J. A novel method for evaluating postoperative adhesions in rats. Journal of Investigative Surgery, in press, 2016.

Peter, C., Fischer, L.K., Kundakovic, M., Garg, P., Jakovcevski, M., Dincer, A., Amaral, A., Ratner, C., Galdzicka, M., Medford, G., Waber, D., Bryce, C.P., Ginns, E.I., Mokler, D., Champagne, F.A., Rosene, D.L., McGaughy, J.A., Sharp, A.J., Galler, J., Akbarian,S. DNA methylation signatures of early childhood malnutrition associated with impairments in attention and cognition. Biological Psychiatry, in press, 2016 DOI: http://dx.doi.org/10.1016/j.biopsych.2016.03.2100

Fischer, L.K., Bradshaw, S.E., McGaughy, J. A., Fitzmaurice, G., Amaral, A.C., Rosene, D.L., Weissner, W., Mokler, D.J., and Galler, J.R.  Prenatal Protein Level Impacts Homing Behavior in Long-Evans Rat Pups., Nutritional Neuroscience 19(5), 187-195, 2016. PMID: 25603489

Amaral, A.C., Jakovcevski, M., McGaughy, J.A., Calderwood, S.K., Mokler, D.J., Rushmore, R.J., Galler, J.R., Akbarian, S.A., Rosene, D.L. Prenatal protein malnutrition decreases kcnj3 and 2dg activity in rat prefrontal cortex. Neuroscience 286, 79-86, 2015. PMID: 25446346

Duncan, J.R., Garland, M., Stark, R.I., Myers, M.M., Fifer, W.P., Mokler, D.J. and Kinney, H.C. Prenatal nicotine exposure selectively affects nicotinic receptor expression in primary and associative visual cortices of the fetal baboon. Brain Pathology 25(2), 171-81, 2015. PMID: 24903536

McGaughy, J.A., Amaral, A.C., Rushmore, R.J., Mokler, D. J.Morgane, P.J., Rosene, D.L., and Galler, J.R. Prenatal malnutrition leads to deficits in attentional set shifting and decreases metabolic activity in prefrontal subregions that control executive function, Developmental Neuroscience 36(6), 532-41, 2014 PMID: 25342495

Rech, R.H., Mokler, D.J. and Briggs, S.L. Effects of Combined Opioids on Pain and Mood in Mammals. Pain Research and Treatment, in press, online, 2012.

Rech, R.H., Briggs, S.L. and Mokler, D.J. Fentanyl and spiradoline interactions in a place-conditioning black-white shuttle-box. Pharmaceuticals 4: 101-116, 2011.

Staiti, A.M., Morgane, P.J., Galler, J.R., Grivetti, J.Y., Bass, D.C., and Mokler, D.J.  A microdialysis study of the medial prefrontal cortex of adolescent and adult rats.  Neuropharmacology 61(3), 544-549, 2011.

Duncan, J.R., Paterson, D.S., Hoffman, J.M., Mokler, D.J., Borestein, N.S., Belliveau, R.A., Krous, H.F., Haas, E.A., Stanley, C., Nattie, E.E., Trachtenberg, F.L. and Kinney, H.C. Brainstem serotonergic deficiency in the sudden infant death syndrome.  Journal of the American Medical Association, 303 (5): 430-437, 2010.

Mokler, D.J., Dugal, J.R., Hoffman, J.M. and Morgane, P.J. Functional interrelations between nucleus raphé dorsalis and nucleus raphé medianus: A dual probe microdialysis study of glutamate-stimulated serotonin release. Brain Research Bulletin, 78 (4-5): 132-138, 2009.

Morgane, P.J. and Mokler, D.J. (eds.) Limbic Brain: Structure and Function. Special Issue, Neuroscience and Biobehavioral Reviews, 30(2), 2006.

Full NLM bibliography

http://www.ncbi.nlm.nih.gov/sites/myncbi/david.mokler.1/bibliography/9041326/public/?sort=date&direction=ascending

Other Scholarly Activity

Mokler, D.J., Rigdon, A., and Schildroth, S. The Herbal Cabinet. Biomedical Sciences Faculty Projects, 2016. Book 1. http://dune.une.edu/biomed_facproj/1

Funded Grants

2007- 2012 National Institute of Mental Health MH 074811, Malnutrition and Mental Health, Janina Galler, M.D., P.I.

2008-2011 Consultant, Inappropriate Use of Prescription Drugs in the Elderly in Maine, Muskie School of Public Service, University of Southern Maine, Susan Payne, MPH., Ph.D., P.I.

2004-2010 Consultant, SIDs Program Project, ChildrenÕs Hospital, Harvard Medical School, Hannah Kinney, M.D., P.I.

Research Topics

David J. Mokler, Ph.D.

David J. Mokler

,

Ph.D.

Professor of Pharmacology

Interim Chair, Department of Biomedical Sciences

Biddeford Campus

Pickus Center
205

dmokler@une.edu

(207) 602-2210

On Campus