Glenn Stevenson

Before joining the faculty in 2005, Dr. Stevenson had two successful careers: one as a professional musician in Boston; the other working for luxury hotel brands in Washington, D.C. and Boston. Dr. Stevenson embarked on his third career by completing a Ph.D. in Behavioral Neuroscience at American University and trained in the Psychopharmacology laboratory of Dr. Anthony L. Riley. Following his graduate training, he did a post-doctoral fellowship in Pharmacology in the laboratory of Dr. Steve Negus at McLean Hopspital / Harvard Medical School.

Education

Ph.D.

American University

2002

M.A.

American University

1992

B.A.

Muhlenberg College

1986

Post-Doctoral Training

Pharmacology

McLean Hospital-Harvard Medical School

2002 - 2005

Expertise

Drug development; preclinical methods development; opioid pharmacology; pain; exercise; drug abuse; drug interactions

Research

Current Research

- Use of novel behavioral strategies and state-of-the-art in vivo imaging to develop new drugs that produce synergistic therapeutic effects and decreased side effects

- Effects of osteoarthritis and neuropathic pain states on cognition, feeding, and wheel running

- Efficacy of wheel running to restore joint function and reduce pain

- Characterization of abuse liability of novel mixed-action delta/mu opioid receptor compounds

Research Interests

- Medications development for the treatment of chronic pain and drug abuse
- Development of reliable and predictive preclinical assays of chronic pain
- Discovery of biomarkers for osteoarthritis
- Characterization of the gut-microbiome-brain axis                                                                                                   - Healing properties of phytochemicals

Selected Publications

(*Signifies UNE undergraduate, COM, or CDM student co-author)

*Cormier J, *Cone K, *Lanpher J, *Kinens A, Henderson T, Liaw L, Bilsky EJ, King T, Rosen CJ, Stevenson GW. Exercise reverses pain-related weight asymmetry and differentially modulates trabecular bone microarchitecture in a rat model of osteoarthritis. Life Sciences, 180:51-19; 2017.

*Warner E, *Krivitsky R, *Cone K, *Atherton P, *Pitre T, *Lanpher J, Giuvelis D, Bergquist I, King T, Bilsky EJ, Stevenson GW. Evaluation of a post-operative pain-like state on motivated behavior in rats: Effects of plantar incision on progressive-ratio food-maintained responding. Drug Development Research, 76(8):432-441; 2015.

Stevenson GW, *Luginbuhl A, *Dunbar C, *LaVigne J, *Dutra J, *Atherton P, *Bell B, *Cone K, Giuvelis D, Polt R, Streicher JM, Bilsky EJ. The mixed-action delta/mu opioid agonist MMP-2200 does not produce conditioned place preference but does maintain drug self-administration in rats, and induces in vitro markers of tolerance and dependence. Pharmacology, Biochemistry and Behavior, 132:49-55; 2015.

Stevenson GW, *Mercer H, *Cormier J, *Dunbar C, *Benoit L, *Adams C, *Jezierski J, *Luginbuhl A, Bilsky EJ. Monosodium iodoacetate-induced osteoarthritis pain-depressed wheel running in rats: Implications for preclinical behavioral assessment of chronic pain. Pharmacology, Biochemistry and Behavior, 98:35-42; 2011.

Negus SS, Bilsky EJ, Do Carmo GP, Stevenson GW. Rationale and methods for assessment of pain-depressed behavior in preclinical assays of pain and analgesia. Methods in Molecular Biology, 617:79-91; 2010.

Stevenson GW, *Cormier J, *Mercer H, *Adams C, *Dunbar C, Negus SS, Bilsky EJ. Targeting pain-depressed behaviors in preclinical assays of pain and analgesia: Drug effects on acetic acid-depressed locomotor activity in ICR mice. Life Sciences, 85(7-8):309-315; 2009.

Pereira Do Carmo G, Stevenson GW, Carlezon WA, Negus SS. Effects of pain- and analgesia-related manipulations on intracranial self-stimulation in rats: Further studies on pain-depressed behavior. Pain, 144(1-2):170-177; 2009.

Negus SS, Schrode K, Stevenson GW. Mu/kappa opioid interactions in rhesus monkeys: Implications for analgesia and abuse liability. Experimental and Clinical Psychopharmacology, 16(5):386-399; 2008.

Stevenson GW, Bilsky EJ, Negus SS. Targeting pain-suppressed behaviors in preclinical assays of pain and analgesia: Effects of morphine on acetic acid-suppressed feeding in C57BL/6J mice. The Journal of Pain, 7(6):408-416; 2006.

Stevenson GW, Folk JE, Rice KC, Negus SS. Interactions between delta and mu opioid agonists in assays of schedule-controlled responding, thermal nociception, drug self-administration, and drug versus food choice in rhesus monkeys: Studies with SNC80 and heroin. The Journal of Pharmacology and Experimental Therapeutics, 314:221-231; 2005.

Funded Grants

NIH (NIAMS) 2R15 AR054975-02A1: Project Title: Characterization of delta/mu opioid receptor interactions on chronic osteoarthritis pain-depressed behaviors and bone / joint pathology. Funding Period: June, 2014-May, 2017. Funding Institute: National Institute of Arthritis and Musculoskeletal and Skin Diseases. Role: Principal Investigator / Award Amount: $366,551

NIH (NIDA) SBIR 2R44DA26653-02: Sub-project Title: Characterization of the reinforcing effects of mixed-action delta/mu opioid receptor compounds using the drug self-administration procedure in rats. Funding Period: April, 2012-March 2013. Funding Institute: National Institute on Drug Abuse. Role: Sub-project PI / Award Amount: $43,058

NIH (NIAMS) R15 AR054975-01 : Project Title: Measurement of pain-suppressed behaviors in rodent models of chronic pain. Funding Period: June, 2007-May 2010. Funding Institute: National Institute of Arthritis and Musculoskeletal and Skin Diseases. Role: PrincipaI Investigator / Award Amount: $212,048

Glenn Stevenson

Glenn Stevenson

,

Ph.D.

Associate Professor

Program Coordinator, Neuroscience Major

Decary Hall
329

gstevenson@une.edu

(207) 602-2285

On Campus