Markus Frederich

M.S. in Zoology, Technical University of Darmstadt, Germany

Ph.D. in Physiology, Alfred Wegener Institute for Polar and Marine Research, University of Bremen, Germany

postdoc in Cardiovascular Biology, Harvard Medical School, Brigham and Women's Hospital, Boston, MA

 

Education

postdoc

Harvard Medical School, Brigham and Women's Hospital, Boston, MA

Ph.D.

University of Bremen, Germany

M.S.

Technical University of Darmstadt, Germany

Post-Doctoral Training

Cardiovascular Physiology 

Harvard Medical School / Brigham and Women's Hospital

Boston

Massachusetts

Clinical Affiliations

Maine

Expertise

Temperature physiology

polar biology

energy metabolism

crustacean biology

marine invertebrates

See our video with a green crab running on a treadmill: http://www.une.edu/cas/marine/crab/

Research

Current Research

Characterizing the role of AMP-activated-protein kinase in temperature thresholds for crustaceans, using methods of physiology and molecular biology.  Investigating differences in stress physiology between the red and green color morph of the invasive green crab, Carcinus maenas

 

Research Interests

Temperature thresholds and adaptation in marine invertebrates, regulation of energy metabolism under stress.

Selected Publications

Undergraduate students underlined

Sokolova IM, Frederich M, Bagwe R, Lannig G, Sukhotin AA (2012) Energy homeostasis as an integrative tool for assessing limits of environmental stress tolerance in aquatic invertebrates. Marine Environmental Research 79: 1-15

Jost JA, Podolski SMFrederich M 2012. Enhancing thermal tolerance by eliminating the pejus range: A comparative study with three decapod crustaceans. Mar Ecol Prog Ser 444, 263-274

Frederich MO’Rourke MFurey N, Jost J (2009) AMP-activated protein kinase (AMPK) affects temperature tolerance in the rock crab, Cancer irroratus. Journal of Experimental Biology, 212: 722-730

Frederich MO’Rourke M, Towle D (2006) Is AMP activated protein kinase expression in Cancer irroratus a better signal for temperature stress than HSP70? The MDIBL Bulletin 45: 37-39

Zhang L, He H, Frederich M, Balschi JA (2006) The relationship between 5-aminoimidazole-4-carboxamide-ribotide and AMP activated protein kinase activity in the perfused mouse heart. Am J Physiol 290: 1235-1243

Pinz I, Perry DFrederich M (2005) Activation of 5’-AMP activated protein kinase during anaerobiosis in the rock crab, Cancer irroratus. The MDIBL Bulletin 44: 31-32

Frederich M, Zhang L, Balschi JA (2005) Hypoxia and AMP independently alter AMP-activated protein kinase activity in heart. Am J Physiol 288: H2412-H2421

Frederich M, Balschi JA (2002) The relationship between AMP-activated protein kinase activity and AMP concentration in the isolated perfused rat heart. J Biol Chem 277/3: 1928-1932

Bock C, Frederich M, Wittig RM, Pörtner HO (2001) Simultaneous observation of haemolymph flow and ventilation in marine spider crabs at different temperatures: a flow weighted MRI study. Magn Res Imag 19: 1113-1124

Frederich M, Sartoris FJ, Pörtner HO (2001) Distribution patterns of decapod crustaceans in polar areas: A result of magnesium regulation? Polar Biology 24/10: 719-723

Frederich M, Sartoris FJ, Arntz WE, Pörtner HO (2000) Haemolymph Mg2+ regulation in decapod crustaceans: physiological correlates and ecological consequences in polar areas. J Exp Biol 203: 1383-1393

Frederich M, Pörtner HO (2000) Oxygen limitation of thermal tolerance defined by cardiac and ventilatory performance in spider crab Maja squinado. Am J Physiol 279: R1531-R1538

Frederich M, DeWachter B, Pörtner HO (2000) Cold tolerance and the regulation of cardiac performance and hemolymph distribution in Maja squinado (Crustacea: Decapoda). Physiol Zool 73/4: 406-415

Other Scholarly Activity

Organizer of the annual Northeast Undergraduate Research and Development Symposium, NURDS, which draws every year about 200 undergraduate researchers from more than 60 different Universities in the Northeast US and Maritime Canada to UNE to present their research.
See www.une.edu/nurds

Funded Grants

NSF research grant: "RUI: Fast and slow cellular response to thermal stress: the role of AMP activated protein kinase and HSP70 in two decapod crustacean species". 2007-2011

NSF grant: "A Synthesis of Education and Research Leading to Graduation (SynER-G) at the University of New England". 2007-2011

American Physiological Society, Research Career Enhancement Award 2005

New Investigator Award from the Maren Foundation at Mount Desert Island Biological Laboratory, Salsbury Cove, ME, 2004 and 2005

Invited Plenary Presentation

Frederich M, Toombs C, Pennoyer K (2012) Color polymorphism in the Green crab, Carcinus maenas: are green morphs really more stress tolerant than red morphs? Annual Meeting of the Society for Integrative and Comparative Biology, Charleston, SC, January 3-7, invited talk

Frederich M (2009) AMPK, a novel cellular marker for acute stress in marine invertebrates. Frenchman Bay Annual Crustacean Symposium, July 13-14, 2009 Salisbury Cove, ME, invited talk

Frederich M (2008) Is AMP-activated protein kinase a better signal for temperature stress than HSP70 in Cancer irroratus? University of Southern Maine, Portland, ME, October 23 2008, invited seminar

Frederich M (2008) Molecular markers for temperature stress in decapod crustaceans. Darling Marine Center, Walpole, ME, invited seminar

Markus Frederich

,

Ph.D.

Assistant Department Chair, Associate Professor

Marine Science Center
218

mfrederich@une.edu

(207) 602-2406