Dr. Hills received his Bachelor of Science from Florida State University in 2003, and his doctorate in molecular biophysics from the Scripps Research Institute in 2008. He completed post-doctoral training from 2008-2010 in the Department of Chemistry at the University of Utah.
Dr. Hills' research involves the development of new simulation methods for studying the molecular biophysics of membrane protein systems. Specific areas of research include the role of lipid-protein interactions in cell function and acquired multidrug resistance associated with ABC transporters.
Scripps Research Institute
B.S., Summa Cum Laude, Biochemistry
Florida State University
NIH Kirschstein Postdoctoral Research Fellow
University of Utah and University of Chicago
molecular dynamics simulation
protein structure and function
- Development of multiscale and coarse-grained models for protein assemblies
- Lipid-protein membrane interactions and protein conformational change
- Multidrug resistance mediated by ABC transporters
Hills Jr., R.D. and N. McGlinchey. 2016. Model parameters for simulation of physiological lipids. J. Comput. Chem. 37:1112. Featured on inside journal cover.
Hills Jr., R.D. 2014. Balancing bond, nonbond and Go-like terms in coarse grain simulations of conformational dynamics. Methods Mol. Biol. 1084:123-40.
Faller, C.E., K.A. Reilly, R.D. Hills Jr. and O. Guvench. 2013. Peptide backbone sampling convergence with the adaptive biasing force algorithm. J. Phys. Chem. B 117:518-26.
Ward, A.B., O. Guvench and R.D. Hills Jr. 2012. Coarse grain lipid-protein molecular interactions and diffusion with MsbA flippase. Proteins 80:2178-90. Featured on Journal Cover.
Jamison II, F.W., T.J. Foster, J.A. Barker, R.D. Hills Jr. and O. Guvench. 2011. Mechanism of binding site conformational switching in the CD44-hyaluronan protein-carbohydrate binding interaction. J. Mol. Biol. 406:631-47.
Hills Jr., R.D., L. Lu and G.A. Voth. 2010. Multiscale coarse-graining of the protein energy landscape. PLoS Comput. Biol. 6:e1000827.
NSF 13-510 proposal no. 1516826 Hills (PI) 9/1/15 – 8/31/18
RUI: Multiscale models for ABC transporter molecular dynamics
Goal: Dissect lipid-protein molecular interactions and mutual adaptation in multidrug exporters.
Role: PI. Total Cost: $374,885
NIH R15 AREA GM099022 Guvench (PI) 9/1/11 – 8/31/15
Molecular Mechanism of Flexible Carbohydrate-Protein Interaction in CD44
Goal: Identify molecular-level interactions governing flexible CD44:hyaluronan binding using computer simulations.
Role: Co-Investigator (5% Effort). Total Cost: $352,480 (one year no-cost extension)