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The Role of Spinal Glial Cell-Mediated Endocannabinoid Signaling in the Resolution of Postoperative Pain

Seminar Center for Excellence in the Neurosciences Seminar Series

Edgar Alfonso Romero-Sandoval, M.D./Ph.D.

Instructor of Anesthesiology Dartmouth-Hitchcock Medical Center


Alfonso received his M.D. from Universidad de San Carlos de Guatemala (a Centro Universitario de Occidente, Quetzaltenango) in 1999 and his PhD in Neuroscience from Universidad de Alcalá, Alcalá de Henares (Madrid), Spain, in 2003. In Spain, he studied the effects and mechanisms of the nitric oxide donor acetaminophen, a new generation of analgesic drugs. His postdoctoral training started in 2003 at the Pain Mechanisms Laboratories, Wake Foest University, Winston Salem, NC, where he studied the role of the peripheral and central immune systems in neuropathic and postoperative pain conditions using alpha-adrenoceptor agonists and cannabinoid drugs. During his postdoctoral training at Wake Forest University, he found that cannabinoid receptors type 2 (CBR2) are functional in spinal cord in pain states, that their activation induces antinociception and glial modulation without the classical cannabinoid neurological side effects. Alfonso joined the DeLeo Lab in 2006 and became a Faculty-Instructor in 2007. He is continuing with studies on the molecular mechanisms of spinal CBR2 activation for induction of analgesia, and the role of endocannabinoids in postoperative pain. His major goal is to find a better and safer drug to treat different types of pain; his recent studies suggest that targeting spinal CBR2 may be a new and safer strategy to treat different pain conditions.


Center for Excellence in Neurosciences


2:00 PM
President's Board Room: Bush Center

Biddeford Campus

Free and open to the public