Joshua Havelin, Ph.D.
Visiting Assistant Teaching Professor
Location
Joshua has a Ph.D. in Biomedical Sciences from the University of Maine Orono. He performed his dissertation work with Dr. Tamara King at the University of New England studying unique roles of subtypes of peripheral sensory neurons in cancer-induced bone pain. After roughly a year as a postdoctoral research associate studying the role of peripheral neurons in diabetic neuropathy he has joined Dr. Ian Meng's research lab at the University of New England and is studying unique circuitry involved in orofacial pain. Joshua continues to volunteer with Dr. Ian Meng and has now assumed the position of Visiting Assistant Teaching Professor in the School of Mathematical and Physcial Sciences in CAS. When he isn't in the lab he enjoys spending time in the great Maine outdoors hunting and fishing.
Credentials
Education
Expertise
Biochemistry
Chemical education
Neuroscience
Nociception
Post-Doctoral Training
Research
Current research
Investigating the effects of cannabinioids in a model of breast cancer metastasis, and establishing various behavioral models for drug candidate screening.
Selected publications
- TIMP-1 attenuates the development of inflammatory pain through MMP-dependent and receptor-mediated cell signaling mechanisms. Brittany E Knight, Nathan Kozlowski, Joshua Havelin, Tamara King, Stephen J Crocker, Erin E Young, Kyle Baumbauer.
- Mechanisms Underlying Bone and Joint Pain. Joshua Havelin, Tamara King. Current Osteoporosis Reports. 2018, 16:763-771.
- A Kappa opioid receptor agonist blocks bone cancer pain without altering bone loss, tumor size, or cancer cell proliferation in a mouse model of cancer-induced bone pain. Edwards, KA; Havelin, JJ; Mcintosh, MI; Ciccone, HA; Pangilinan, K; Imbert, I; Largent-Milnes, TM; King, T; Vanderah, TW; Streicher, JM. The Journal of Pain. 22, January 2018. S1526-5900 epub
- Mediation of movement-induced breakthrough cancer pain by IB4 binding nociceptors in rats. Joshua Havelin, Ian Imbert, Devki Sukhtankar, Bethany Remeniuk, Ian Pelletier, Jonathan Gentry, Alec Okun, Timothy Tiutan, Frank Porreca, Tamara King. Journal of Neuroscience. 24 April 2017, 1212-16
- Effects of treadmill exercise on advanced osteoarthritis pain in rats. Allen, Joshua; Imbert, Ian; Havelin, Joshua; Henderson, Terry; Stevenson, Glenn; Liaw, Lucy; King, Tamara. In press. Arthritis and Rheumatology. 2017, 69: 1407-1417
- Central sensitization and neuropathic features of ongoing pain in a rat model of advanced osteoarthritis. Havelin, Joshua; Imbert, Ian; Cormier, Jennifer; Allen, Joshua; Porreca, Frank; King, Tamara. The Journal of Pain. March 2016, Volume 17, Issue 3, Pages 374-382
- Disease modification of breast cancer-induced bone remodeling by cannabinoid 2 receptor agonists. Lozano-Ondoua AN1, Hanlon KE, Symons-Liguori AM, Largent-Milnes TM, Havelin JJ, Ferland HL 3rd, Chandramouli A, Owusu-Ankomah M, Nikolich-Zugich T, Bloom AP, Jimenez-Andrade JM, King T, Porreca F, Nelson MA, Mantyh PW, Vanderah TW. Journal of Bone and Mineral Research. January 2013 (1) 92-107
Other scholarly activity
UNE spring undergraduate research symposium: Oral presentation review of the drug "Modafinil" in the spring of 2010, and a poster presentation "The effects of MMP-2200 in an animal model of overactive Bladder" in the spring of 2011.
Research interests
Function and dysfunction of subtypes of peripheral sensory neurons, mechanisms driving unique characteristics of cancer-induced bone pain, role of glial cells in modulation of peripheral sensory neurons, unique mechanisms and circuitry driving orofacial pain.