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Mark Brezinski MD,PhD, CPT

Mark Brezinski, M.D., Ph.D., CPT

Clinical Professor

Location

On campus
Eligible for Student Opportunities

My entire career (and training), prior to joining the UNE team part time in 2015, has been faculty at Harvard Medical School, Massachusetts Institute of Technology, Brigham and Women’s Hospital, and Massachusetts General Hospital.  This has been as a researcher, educator, and physician. 

Research- My group’s research can be divided into two areas, clinical and basic science.  

Basic: Our basic science work has been, since the early 1990’s, focused on the development and clinical application of Optical Coherence Tomography (OCT).  This work spans technology developments, physics, bench-top studies, and clinical trials.  It is now FDA approved in cardiology, ophthalmology, and gastroenterology.  OCT research at UNE is focused on detecting plaques that cause heart attacks, identifying early arthritis, and correcting labrum entrapment of the hip.  Accolades for this work include winning the Investigator Award for Scientists and Engineers from President Clinton and being named one of the forty top pioneering researchers in Brigham and Women’s Hospital first 100 years, published in the BWH millennium celebration book  (The Teaching Hospital).  This has represented in excess of 150 peer reviewed publications, over 12 NIH R01’s (in addition to other organizational support) and authoring almost all chapters in OCT Principles and Practice.  In addition to other government agencies, I have participated in over 80 NIH panels and study sections.

Basic: Our clinical research is focused on clinical practice is non-surgical joint restoration, injury prevention, and fitness.  We have ongoing clinical trials in gait correction, risk stratifying patellofemoral syndrome, and establishing the role of scapula dysfunction in rotator cuff injuries.

Clinical- My outpatient focus is non-surgical joint restoration, injury prevention, and fitness.  My inpatient efforts are internal medicine and cardiology.  The program is heavily waited to correct gait to prevent osteoarthritis and training physicians to practice in fitness centers.

Musculoskeletal Disease Prevention     

https://www.youtube.com/watch?v=t6SXiDCMP3E&t=20s

https://www.youtube.com/watch?v=sVub-q5Wkqw

Optical Coherence Tomography in Cardiology and Musculoskeletal Disease

https://www.youtube.com/watch?v=XpAwPwuQ6iU&t=14s

Identifying the Mechanisms of Heart Attacks

https://www.youtube.com/watch?v=ulKGEBXqClA&t=9s

Optical Coherence Tomography Development (Duke University Talk)

https://www.youtube.com/watch?v=6lW1jEpvsvI&t=1360s

Optical Coherence Tomography in Nontransparent Tissue (other than the eye)

https://www.youtube.com/watch?v=RJIjABVNHUE&list=PLH-n-DlpSDIhp849XAWdJxSJcX7uD3VNZ&index=3&t=1464s

Credentials

Expertise

Acute care Cardiology Functional fitness Knee osteoarthritis Physical diagnosis

Clinical Affiliations

Harvard Medical School

Massachusetts Institute of Technology

Massachusetts General Hospital

Brigham and Women's Hospital

Board Certifications and Licenses

Internal Medicine

Cardiology

Post-Doctoral Training

Combined Internal Medicine/Post doctoral fellowship - Brigham and Women's Hospital/Harvard Medical School

Cardiology - Massachusetts General Hospital/Harvard Medical School

Research

Selected publications

Original Reports (of >150, * are trainees):

 1. 

16. Brezinski ME, Serhan CN. Selective incorporation of (15S)-hydroxyeicosatetraenoic acid in phosphatidylinositol of human neutrophils: agonist-induced deacylation and transformation of stored hydroxyeicosanoids. Proc Natl Acad Sci U S A. 1990 Aug; 87(16):6248-52.

17. Fiore S, Brezinski ME, Sheppard KA, Serhan CN. The lipoxin biosynthetic circuit and their actions with human neutrophils. Adv Exp Med Biol. 1991; 314:109-32.

18. Brezinski ME, Serhan CN, . Selective incorporation of 15-HETE in phosphatidylinositol: agonist-induced deacylation and transformation of stored HETEs by human neutrophils. Adv Prostaglandin Thromboxane Leukot Res. 1991; 21A:105-8.

19. Bouma B, Tearney GJ*, Boppart SA*, Hee MR, Brezinski ME, Fujimoto JG. High-resolution optical coherence tomographic imaging using a mode-locked Ti-Al2O3 laser source. Optics Letters. 1995 Jul; 1;20(13):1486-8.

20. Fujimoto JG, Brezinski ME, Tearney GJ*, Boppart SA, Bouma B, Hee MR, Southern JF, Swanson EA. Optical biopsy and imaging using optical coherence tomography. Nat Med. 1995 Sep; (9):970-2.

21. Tearney GJ*, Brezinski ME, Southern JF, Bouma BE, Hee MR, Fujimoto JG. Determination of the refractive-index of highly scattering human tissue by optical coherence tomography. Optics Letters. 1995 Nov; 1;20(21):2258-60.

22. Brezinski ME, Tearney GJ*, Bouma BE, Boppart SA, Hee MR, Swanson EA, Southern JF, Fujimoto JG. Imaging of coronary artery microstructure (in vitro) with optical coherence tomography. Am J Cardiol. 1996 Jan; 1;77(1):92-3.

23. Brezinski ME, Tearney GJ*, Bouma BE, Izatt JA, Hee MR, Swanson EA, Southern JF, Fujimoto JG. Optical coherence tomography for optical biopsy. Properties and demonstration of vascular pathology. Circulation. 1996 Mar; 15;93(6):1206-13.

24. Tearney GJ*, Boppart SA*, Bouma BE, Brezinski ME, Weissman NJ, Southern JF, Fujimoto JG. Scanning single-mode fiber optic catheter-endoscope for optical coherence tomography. Optics Letters 1996 Apr 1; 21(7): 543-5

25. Boppart SA*, Brezinski ME, Bouma BE, Tearney GJ*, Fujimoto JG. Investigation of developing embryonic morphology using optical coherence tomography. Dev Biol. 1996 Jul 10; 177(1): 54-63.

26. Tearney GJ*, Brezinski ME, Boppart SA*, Bouma BE, Weissman N, Southern JF, Swanson EA, Fujimoto JG. Images in cardiovascular medicine. Catheter-based optical imaging of a human coronary artery. Circulation. 1996 Dec; 1; 94(11):3013.

27. Boppart SA*, Bouma BE, Brezinski ME, Tearney G*, Fujimoto JG. Imaging developing neural morphology using optical coherence tomography. J Neurosci Methods. 1996 Dec; 70(1): 65-72.

28. Boppart SA*, Tearney GJ*, Bouma BE, Southern JF, Brezinski ME, Fujimoto JG.  Noninvasive assessment of the developing Xenopus cardiovascular system using optical coherence tomography. Proc Natl Acad Sci U S A. 1997 Apr 29; 94(9): 4256-61.

29. Tearney GJ*, Brezinski ME, Southern JF, Bouma BE, Boppart SA*, Fujimoto JG. Optical biopsy in human urologic tissue using optical coherence tomography. J Urol. 1997 May; 157(5):1915-9.

30. Brezinski ME, Tearney GJ*, Weissman NJ, Boppart SA*, Bouma BE, Hee MR, Weyman AE, Swanson EA, Southern JF, Fujimoto JG. Assessing atherosclerotic plaque morphology: comparison of optical coherence tomography and high frequency intravascular ultrasound. Heart. 1997 May; 77(5):397-403.

31. Tearney GJ*, Brezinski ME, Bouma BE, Boppart SA*, Pitris C*, Southern JF, Fujimoto JG. In vivo endoscopic optical biopsy with optical coherence tomography. Science. 1997 Jun 27; 276(5321):2037-9.

32. Brezinski ME, Tearney GJ*, Boppart SA*, Swanson EA, Southern JF, Fujimoto JG. Optical biopsy with optical coherence tomography: feasibility for surgical diagnostics. J Surg Res. 1997 Jul 15; 71(1):32-40.

33. Tearney GJ*, Brezinski ME, Southern JF, Bouma BE, Boppart SA*, Fujimoto JG. Optical biopsy in human gastrointestinal tissue using optical coherence tomography. Am J Gastroenterol. 1997 Oct; 92(10):1800-4.

34. Boppart SA*, Bouma BE, Pitris C*, Tearney GJ*, Fujimoto JG, Brezinski ME Forward-imaging instruments for optical coherence tomography. Optics Lettrs. 1997 Nov 1; 22(21):1618-20

35. Brezinski ME, Tearney GJ*, Bouma B, Boppart SA*, Pitris C*, Southern JF, Fujimoto JG. Optical biopsy with optical coherence tomography. Ann N Y Acad Sci. 1998 Feb 9; 838:68-74.

36. Pitris C*. Brezinski ME, Bouma BE, Tearney GJ*, Southern JF, Fujimoto JG. High resolution imaging of the upper respiratory tract with optical coherence tomography: a feasibility study. Am J Respir Crit Care Med. 1998 May; 157(5 Pt 1):1640-4.

37. Boppart SA*, Bouma BE, Pitris C*, Tearney GJ*, Southern JF, Brezinski ME, Fujimoto JG. Intraoperative assessment of microsurgery with three-dimensional optical coherence tomography. Radiology. 1998 Jul; 208(1):81-6.

38. Tearney GJ*, Brezinski ME, Southern JF, Bouma BE, Boppart SA*, Fujimoto JG. Optical biopsy in human pancreatobiliary tissue using optical coherence tomography. Dig Dis Sci. 1998 Jun; 43 (6): 1193-9.

39. Fujimoto JG, Bouma B, Tearney GJ, Boppart SA, Pitris C, Southern JF, Brezinski ME. New technology for high-speed and high-resolution optical coherence tomography. Ann N Y Acad Sci. 1998 Feb 9;838:95-107.

40. Herrmann JM*, Brezinski ME, Bouma BE, Boppart SA*, Pitris C*, Southern JF, Fujimoto JG. Two- and three-dimensional high-resolution imaging of the human oviduct with optical coherence tomography. Fertil Steril. 1998 Jul; 70(1):155-8.

42. Boppart SA*, Bouma BE, Pitris C*, Southern JF, Brezinski ME, Fujimoto JG. In vivo cellular optical coherence tomography imaging. Nat Med. 1998 Jul; 4(7):861-5.

43. Boppart SA*, Brezinski ME, Pitris C,* Fujimoto JG. Optical coherence tomography for neurosurgical imaging of human intracortical melanoma. Neurosurgery. 1998 Oct;43(4):834-41.

44. Pitris C*, Goodman A, Boppart SA*, Libus JJ, Fujimoto JG, Brezinski ME. High-resolution imaging of gynecologic neoplasms using optical coherence tomography. Obstet Gynecol. 1999 Jan; 93(1):135-9.

45. Herrmann JM*, Pitris C*, Bouma BE, Boppart SA*, Jesser CA*, Stamper DL, Fujimoto JG, Brezinski ME. High resolution imaging of normal and osteoarthritic cartilage with optical coherence tomography. J Rheumatol. 1999 Mar; 26(3):627-35.

46. Boppart SA*, Herrmann J*, Pitris C*, Stamper DL, Brezinski ME, Fujimoto JG.  High-resolution optical coherence tomography-guided laser ablation of surgical tissue.  J Surg Res. 1999 Apr; 82(2):275-84.

47.  Brezinski ME, Fujimoto JG. Optical coherence tomography: High-resolution imaging in nontransparent tissue. IEEE J Select Top Quantum Electron. 1999 Jul-Aug; 5(4):1185-92

48.  Fujimoto JG, Boppart SA*, Tearney GJ*, Bouma BE, Pitris, C*, Brezinski ME.  High resolution in vivo intra-arterial imaging with optical coherence tomography.  Heart. 1999 Aug; 82(2):128-33.

49. Boppart SA*, Goodman A, Libus J, Pitris C*, Jesser CA*, Brezinski ME, Fujimoto JG. High-resolution imaging of endometriosis and ovarian carcinoma with optical coherence tomography: feasibility for laparoscopic-based imaging. Br J Obstet Gynaecol. 1999 Oct; 106(10):1071-7.

50. Pitris C*, Jesser C*, Boppart SA*, Stamper D, Brezinski ME, Fujimoto JG.  Feasibility of optical coherence tomography for high-resolution imaging of human gastrointestinal tract malignancies.  J Gastroenterol. 2000; 35(2):87-92.

51. Jesser CA*, Boppart SA*, Pitris C*, Stamper D., Nielsen GP, Brezinski ME, Fujimoto JG. High resolution imaging of transitional cell carcinoma with optical coherence tomography: feasibility for the evaluation of bladder pathology. Br J Radiol. 1999 Dec; 72(864):1170-6.

52. Boppart SA*, Brezinski ME, Fujimoto JG.  Optical coherence tomography imaging in developmental biology. Methods Mol Biol. 2000; 135:217-33.

53. Patwari P*, Weissman NJ, Boppart SA*, Jesser C*, Stamper D, Fujimoto JG, Brezinski ME. Assessment of coronary plaque with optical coherence tomography and high-frequency ultrasound. Am. J Cardiol. 2000 Mar 1; 85(5):641-4.

54. Li XD*, Boppart SA*, Van Dam J, Mashimo H, Mutinga M, Drexler W, Klein M, Pitris C,.*, Krinsky ML, Brezinski ME, Fujimoto JG. Optical coherence tomography: advanced technology for the endoscopic imaging of Barrett’s esophagus. Endoscopy. 2000 Dec; 32(12):921-30.

55. Rogowska J, Brezinski ME. Evaluation of the adaptive speckle suppression filter for coronary optical coherence tomography imaging. IEEE Trans Med Imaging. 2000 Dec; 19(12):1261-6.

56. Fujimoto JG, Pitris C, Boppart SA, Brezinski ME.  Optical coherence tomography: an emerging technology for biomedical imaging and optical biopsy.  Neoplasia. 2000 Jan-Apr;2(1-2):9-25.

57. Pitris C*, Saunders KT*, Fujimoto JG, Brezinski ME. High-resolution imaging of the middle ear with optical coherence tomography: a feasibility study. Arch Otolaryngol Head Neck Surg. 2001 Jun; 127(6):637-42.

58. Drexler W*, Stamper D, Jesser C*, Li X*, Pitris C*, Saunders K*, Martin S, Lodge MB*, Fujimoto JG, Brezinski ME. Correlation of collagen organization with polarization sensitive imaging of in vitro cartilage: implications for osteoarthritis. J Rheumatol. 2001 Jun; 28(6):1311-8.

59. Boppart SA*, Herrmann JM*, Pitris C*, Stamper DL, Brezinski ME, Fujimoto JG. Real-time optical coherence tomography for minimally invasive imaging of prostate ablation. Comput Aided Surg. 2001; 6(2):94-103.

60. Brezinski M, Saunders K*, Jesser C*, Li XD, Fujimoto J. Index matching to improve optical coherence tomography imaging through blood. Circulation. 2001; 103(15):1999-03.

61  Brezinski M. Characterizing arterial plaque with optical coherence tomography. Current sOpinion In Cardiology 2002;17(6):648-55.         

62. Rogowska J, Brezinski ME. Image processing techniques for noise removal, enhancement and segmentation of cartilage OCT images. Phys Med Biol. 2002 Feb 21; 47(4):641-55.

63. Schenk JO*, Brezinski ME. Ultrasound induced improvement in optical coherence tomography (OCT) resolution. Proc Natl Acad Sci U S A. 2002 Jul 23; 99(15):9761-4.

64. Rogowska J, Bryant CM, Brezinski ME. Cartilage thickness measurements from optical coherence tomography. J Opt Soc Am A Opt Image Sci Vis. 2003 Feb; 20(2): 357-67.

65. Patel NA*, Li Xiang*, Stamper DL, Fujimoto JG, Brezinski ME. Guidance of aortic ablation using optical coherence tomography. Int J Cardiovasc Imaging. 2003 Apr; 19(2): 171-8.

66. Martin SD, Patel NA*, Adams SB Jr*, Roberts MJ*, Plummer S*, Stamper DL, Brezinski ME, Fujimoto JG. New technology for assessing microstructural components of tendons and ligaments. Int Orthop. 2003; 27(3):184-9. Epub 2003 Feb 5.

67. Niblack WK, Schenk JO*, Liu B*, Brezinski ME. Dispersion in a grating-based optical delay line for optical coherence tomography. Appl Opt. 2003 Jul 1; 42(19):4115-8.

68. Roberts MJ*, Adams SB Jr*, Patel NA*, Stamper DL, Westmore MS, Martin SD, Fujimoto JG, Brezinski ME. A new approach for assessing early osteoarthritis in the rat. Anal Bioanal Chem. 2003 Nov; 377(6):1003-6. Epub 2003 Oct 15.

69. Rogowska J, Patel NA*, Fujimoto JG, Brezinski ME. Optical coherence tomographic elastography technique for measuring deformation and strain of atherosclerotic tissues. Heart. 2004 May; 90(5): 556-62.

70. Liu B*, Macdonald EA*, Stamper DL, Brezinski ME. Group velocity dispersion effects with water and lipid in 1.3 micron optical coherence tomography system. Phys Med Biol. 2004 Mar 21; 49(6): 923-30.

71. Patel NA*, Zoeller J*, Stamper DL, Fujimoto JG, Brezinski ME.  Monitoring osteoarthritis in the rat model using optical coherence tomography. IEEE Trans Med Imaging. 2005 Feb; 24(2):155-9.

72. Patel NA, Stamper DL, Brezinski ME. Ability of optical coherence tomography to characterize plaque, including a comparison with intravascular ultrasound. Cardiovasc Intervent Radiol. 2005 Jan-Feb;28(1):1-9.

73. Liu B*, Harman M*, Brezinski ME. Variables affecting polarization-sensitive optical coherence tomography imaging examined through the modeling of birefringent phantoms. J Opt Soc Am A Opt Image Sci Vis. 2005 Feb; 22(2):262-71.

74. Li X*, Martin S, Pitris C*, Ghanta R*, Stamper DL, Harman M*, Fujimoto JG, Brezinski ME. High-resolution optical coherence tomographic imaging of osteoarthritic cartilage during open knee surgery. Arthritis Res Ther. 2005; 7(2): R318-23. Epub  2005 Jan 17.

75. Patel NA*, Li X*, Stamper DL, Fujimoto JG, Brezinski ME. Using optical coherence tomography to guide articular cartilage ablation. Am J Orthop. 2005 Mar; 34(3):111-5.

76. Giattina SD*, Courtney BK*, Herz PR*, Harman M*, Shortkroff S, Stamper DL, Liu B*, Fujimoto JG, Brezinski ME, "Assessment of coronary plaque collagen with polarization sensitive optical coherence tomography (PS-OCT)," International Journal Of Cardiology 107, 400-409 (2006).

77. Adams SB*, Herz PR*, Stamper DL, Roberts MJ*, Bourquin S, Patel NA*, Schneider K*, Martin SD, Shortkroff S, Fujimoto JG, and Brezinski ME. High resolution imaging of progressive articular cartilage degeneration. Journal of Orthopaedic Research, 2006; 24: 708-715.

78. Liu B*, Harman M*, Giattina S*, Stamper DL, Demakis C*, Chilek M*, Stephanie Raby and Brezinski ME. Characterizing of tissue microstructure with single detector polarization sensitive optical coherence tomography. Applied Optics. 2006; 45: 4464-4479

79  Stamper, D, Weissman, NJ, Brezinski, ME. Plaque characterization with OCT. J. American Coll. Cardiology. 2006; 47:C69-79.

80. Brezinski ME.  Optical coherence tomography for identifying unstable coronary plaque.

      Int’l J. Cardiol. 2006 Feb 15;107(2):159-70. Epub 2005 Nov 9.

81. Rogowska J, Patel N*, Plummer S, Brezinski ME. Quantitative optical coherence tomographic  elastography: method for assessing arterial mechanical properties. British J. Radiology. 2006;  79:707-11.

82. Liu, B. and M.E. Brezinski. Theoretical and practical considerations on detection of time domain, Fourier domain, and swept source OCT. J. Biomed. Optics, 12, 044007, 2007.

83. M.E. Brezinski. Applications of optical coherence tomography to cardiac and musculoskeletal diseases: bench to bedside? J. Biomed. Optics, 12, 051705, 2007.

84. Huang CY*, Liu B, and Brezinski ME, Characterization of Improved Penetration and Resolution with Ultrasound Enhanced Optical Coherence Tomography, J. Opt. Soc. Am. A, 25, 938, 2008.

  1. Mark E. Brezinski and Bin Liu, Nonlocal Quantum Macroscopic Superposition in High-thermal low purity state, Physical Review A, 78, 063824, 2008.
  2. K. Zheng*, B. Liu, C. Y. Huang*, and M. E. Brezinski. Experimental conformation of SS-OCT Performance Limitations, Applied Optics, 45, 938, 2008.
  3. Zheng, K.*, Rupnick, R.A., Liu, B., and Brezinski, M.E., Three dimensional OCT in the engineering of tissue contstructs: a potential powerful tool for assign optimal scaffold structure, The Open Tissue Engineering & Regenerative Medicine, 1, 30-35, 2008.
  4. Zheng, K., Rashidifard, C.*, Liu, B., and Brezinski, M.E.2009, Comparison of artifact Generation with catheter bending using different PS-OCT approaches, Reports in Medical Imaging, 2, 49-54.
  5. E. Azimi*, B. Liu, and M. E. Brezinski, "Real-time and high-performance calibration method for high-speed swept-source optical coherence tomography," Journal Of Biomedical Optics 15, 016005 (2010).
  6. B. Liu, E. Azimi*, and M. E. Brezinski, "Improvement in dynamic range limitation of swept source optical coherence tomography by true logarithmic amplification," Journal Of The Optical Society Of America A-Optics Image Science And Vision 27, 404-414 (2010).
  7. K. Zheng*, S. D. Martin, C. H. Rashidifard*, B. Liu, and M. E. Brezinski, "In vivo micron-scale arthroscopic imaging of human knee osteoarthritis with optical coherence tomography: comparison with magnetic resonance imaging and arthroscopy," Am. J. Orthop. 39, 122-125 (2010).
  8. M. E. Brezinski, "Current Capabilities and Challenges for Optical Coherence Tomography as a High-Impact Cardiovascular Imaging Modality," Circulation 123, 2913-2915 (2011).
  9. B. Liu, E. Azimi*, and M. E. Brezinski, "True logarithmic amplification of frequency clock in SS-OCT for calibration," Biomedical Optics Express 2, 1769-1777 (2011).
  10. M. E. Brezinski, "The advantages of not entangling macroscopic diamonds at room temperature," Journal of Atomic, Molecular, and Optical Physics 2012, 1-9 (2012).
  11. M. E. Brezinski, "Nonlocal quantum correlations: beyond entanglement," ArXiv, 1209.1081 (2012).
  12. B. Liu, C. Vercollone*, and M. E. Brezinski, "Towards improved collagen assessment: polarization-sensitive optical coherence tomography with tailored reference arm polarization," International Journal of Biomedical Imaging 2012, 892680 (2012).
  13. C. Rashidifard*, S. Martin, N. Kumar*, E. Azimi*, B. Liu, and M. E. Brezinski, "Single-detector polarization-sensitive optical coherence tomography for assessment of rotator cuff tendon integrity," American journal of orthopedics 41, 351-357 (2012).
  14. C. Vercollone*, C. H. Rashidifard*, S. Zan*, S. D. Martin, and M. E. Brezinski, "New technological approach to study rotator cuff pathology," Journal of Musculosketal Research 15, 1250010 (2012).
  15. C. Rashidifard*, C. Vercollone*, S. Martin, B. Liu, and M. E. Brezinski, "The application of optical coherence tomography in musculoskeletal disease," Arthritis 2013, 563268 (2013).
  16. M. E. Brezinski, "A quantum field approach for advancing optical coherence tomography Part I: First order correlations, single photon interference, and quantum noise," ArXiv, 1402.1722 (2014).
  17. M. E. BrezinskiCapabilities, limitations, and misconceptions of using OCT to assess vulnerable plaques” Nature Cardiology Reviews. 10: pp. 62-63, 2014.
  18. M. E. Brezinski and K. HarjaiLongitudinal Necrotic Shafts Near TCFAs - A Potential Novel Mechanism for Plaque Rupture to Trigger ACS?” International Journal of Cardiology 2014  
  19. M. E. Brezinski “Practical Limitations of Current OCT Elastography and a Top Down Approach for Overcoming Them” Journal of Laser Optics & Photonics 2014, 1:2
  20. M. E. Brezinski and K. HarjaiCurrent OCT Approaches Do Not Identify TCFAs.” J Clin Exp Cardiolog. 2014 Nov; 5(11): 350.
  21. M. E. Brezinski, A Quantum Field Approach for Advancing Optical Coherence Tomography Part I: First Order Correlations, Single Photon Interference, and Quantum Noise,  J Lasers Opt Photonics 2018; 5(1)176.
  22. M.E. Brezinski Comparing the Risk Factors of Plaque Rupture and Failed Plaque Healing in Acute Coronary Syndrome. JAMA Cardiol. Published online March 13, 2019 (4):329–331. doi:10.1001/jamacardio.2019.0312

107.     M.E. Brezinski, F. Willard, M.A. Rupnick.   Inadequate Intimal Angiogenesis as a Source of Coronary Plaque Instability.  Circulation 2019;140:1857–1859

Research topics

COM Faculty Research

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