University of Virginia
Chemistry Department (synthetic organic)
University of Vermont
Small molecule design
& spectroscopic characterization; synthesis of biologically active
nitrogen-containing heterocycles with applications to chemotherapy and pain; the design and synthesis of exotic amino acids; total synthesis of natural p
I presently have three ongoing research projects in my laboratory: (1) the design and semisynthesis of novel opioid derivatives for the treatment of pain and addiction; (2) the design and synthesis of novel DNA intercalators; (3) the development of greener methods for organic synthesis and their pedagogical application.
Andrea L. Pelotte, Ryan M. Smith, Mario Ayestas, Christina M. Dersch, Edward J. Bilsky, Richard B. Rothman, Amy M. Deveau. Design, Synthesis, and Characterization of 6_-Naltrexol Analogs, and Their Selectivity for In Vitro Opioid Receptor Subtypes. Bioorganic & Medicinal Chemistry Letters, 2009, 19, 2811-2814.
Amy M. Deveau, Nancy E. Costa, Elizabeth M. Joshi, Timothy L. Macdonald. Synthesis of Carboline Homodimers, and Evaluation in In Vitro Carcinoma Lines. Bioorganic and Medicinal Chemistry Letters 2008, 18, 12, 3522-3525.
H.D. Jain, C. Zhang, S. Zhou, H. Zhou, J. Ma, X. Liu, X. Liao, Amy M. Deveau, Christine M. Dieckhaus, Michael A. Johnson, Kirsten S. Smith, Timothy L. Macdonald, H. Kakeya, H. Osada and James M. Cook. Synthesis and structure_activity relationship studies on tryprostatin A, a potent inhibitor of breast cancer resistance protein. Bioorganic & Medicinal Chemistry 2008, 16, 4626-4651.