Kristin M. Burkholder

Education

Ph.D.

Purdue University

2014

B.S.

Virginia Tech

2014

M.S.

Purdue University

2014

Post-Doctoral Training

Dept. of Microbiology and Immunology

University of Michigan Medical School

Ann Arbor

Michigan

Clinical Affiliations

Maine

Expertise

Microbiology and the biology of infection

Research

Current Research

My lab studies how bacterial pathogens infect and survive within the cells of their host. I am particularly interested in strategies used by pathogens to avoid destruction by host innate intracellular defenses.

Research Interests

Bacterial pathogenesis and host-pathogen interactions

Selected Publications

Burkholder, K.M. and A.K. Bhunia.  2013.  Listeria monocytogenes and human Hsp60 - an invasive pairing, p 267-282.  In Henderson B (ed), Moonlighting cell stress proteins in microbial infections.  Springer, New York, NY.

Burkholder, K.M., J. Perry, C. Wobus, H. Showalter, V. Kapuria, N. Donato and M.X.D. OÕRiordan.  2011.  A small molecule deubiquitinase inhibitor increases localization of iNOS to the macrophage phagosome and enhances bacterial killing.  Infection and Immunity. 12:4850-7.

Mishra, K.K., Mendonca, M., Aroonnual, A., Burkholder, K.M. and Bhunia, A.K.  2011. Genetic organization and molecular characterization of the secA2 locus in Listeria species. Gene.  489:76-85.

Burkholder, K.M and Bhunia, A.K. 2010. Listeria monocytogenes uses Listeria Adhesion Protein (LAP) to promote bacterial transepithelial translocation, and induces expression of LAP receptor Hsp60.  Infection and Immunity.  78: 5062-5073.

Jagadeesan B., Koo O.-K., Kim K.-P., Burkholder K.M., Mishra K., Aroonnual A., Bhunia A.K.  2010. LAP, an alcohol acetaldehyde dehydrogenase enzyme in Listeria, promotes bacterial adhesion to enterocyte-like Caco-2 cells only in pathogenic species.  Microbiology. 156: 2782-95.

Burkholder, K.M., Kim, K-P., Mishra, K., Medina, S., Hahm, B-K., Kim, H., and Bhunia, A.K. 2009. Expression of LAP, a SecA2-dependent secretory protein, is induced under anaerobic environment. Microbes and Infection. 11: 859-867.

Burkholder, K.M. and Bhunia, A.K. 2009. Salmonella enterica serovar Typhimurium adhesion and cytotoxicity during epithelial cell stress is reduced by Lactobacillus rhamnosus GG. Gut Pathogens. 1: 14.

Burkholder, K.M., K.L. Thompson, T.A. Applegate and J.A. Patterson.  2008.  Influence of stressors on normal intestinal microbiota, intestinal morphology and susceptibility to Salmonella Enteriditis colonization in broilers.  Poultry Science. 87: 1734-1741.


Akin, D., J. Sturgis, K. Ragheb, D. Sherman, K.M. Burkholder, J.P. Robinson, A.K. Bhunia, S. Mohammed, and R. Bashir. 2007. Bacteria-mediated delivery of nanoparticles into cells. Nature Nanotechnology. 2: 441-449.

Kim, K.-P., B. Jagadeesan, K.M. Burkholder, Z.W. Jaradat, J.L. Wampler, A.A. Lathrop, M.T. Morgan, and A.K. Bhunia. 2006.  Adhesion characteristics of Listeria adhesion protein (LAP)-expressing Escherichia coli to Caco-2 cells and of recombinant LAP to eukaryotic receptor Hsp60 as examined in a surface plasmon resonance sensor.  FEMS Microbiology Letters.  256: 324-332.

 

Kristin M. Burkholder

,

Ph.D.

Assistant Professor