Ron Hills

Dr. Ron Hills is Associate Professor of Pharmaceutical Sciences at the University of New England in Portland, Maine. He teaches biochemistry to the pharmacy students and conducts research in computer modeling.

Dr. Hills received his Bachelor of Science from Florida State University in 2003, and his doctorate in molecular biophysics from the Scripps Research Institute in 2008. He completed post-doctoral training from 2008-2010 in the Department of Chemistry at the University of Utah.

Researchers in the Hills Lab work on the development of new simulation methods for studying the molecular biophysics of membrane protein systems. Topics of focus include the role of lipid-protein interactions in cell function and acquired multidrug resistance associated with ABC transporters.

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Education

Ph.D., Biophysics

Scripps Research Institute

2009

B.S., Summa Cum Laude, Biochemistry

Florida State University

2003

Post-Doctoral Training

NIH Kirschstein Postdoctoral Research Fellow

University of Utah and University of Chicago

Expertise

molecular dynamics simulation

protein structure and function

multiscale modeling

Research

Research Interests

  • Development of multiscale and coarse-grained models for protein assemblies
  • Lipid-protein membrane interactions and protein conformational change
  • Multidrug resistance mediated by ABC transporters

Selected Publications

Hills Jr., R.D. 2018. Refining amino acid hydrophobicity for dynamics simulation of membrane proteins. PeerJ 6:e4230.

Fosso-Tande, J., C. Black, S.G. Aller, L. Lu and R.D. Hills Jr. 2017. Simulation of lipid-protein interactions with the CgProt force field. AIMS Mol. Sci. 4:352-69.

Hills Jr., R.D. and N. McGlinchey. 2016. Model parameters for simulation of physiological lipids. J. Comput. Chem. 37:1112-18. Featured on inside journal cover. 

Faller, C.E., K.A. Reilly, R.D. Hills Jr. and O. Guvench. 2013. Peptide backbone sampling convergence with the adaptive biasing force algorithm. J. Phys. Chem. B 117:518-26.

Ward, A.B., O. Guvench and R.D. Hills Jr. 2012. Coarse grain lipid-protein molecular interactions and diffusion with MsbA flippase. Proteins 80:2178-90. Featured on Journal Cover.

Funded Grants

NSF 13-510 proposal no. 1516826 Hills (PI) 9/1/15 – 8/31/18
RUI: Multiscale models for ABC transporter molecular dynamics
Goal: Dissect lipid-protein molecular interactions and mutual adaptation in multidrug exporters.
Role: PI. Total Cost: $374,885

NIH R15 AREA GM099022 Guvench (PI) 9/1/11 – 8/31/15
Molecular Mechanism of Flexible Carbohydrate-Protein Interaction in CD44
Goal: Identify molecular-level interactions governing flexible CD44:hyaluronan binding using computer simulations.
Role: Co-Investigator (5% Effort). Total Cost: $352,480 (one year no-cost extension)

Ronald Hills

Ron Hills

,

Ph.D.

Associate Professor

Portland Campus

Pharmacy Building
305

rhills@une.edu

(207) 221-4049

On Campus

Eligible for Student Opportunities