Steven (Steev) C Sutton

Dr. Steven 'Steev' C. Sutton received his B.S. Pharmacy from Massachusetts College of Pharmacy, Boston, and his Ph.D. in Pharmaceutical Sciences from the State University of New York at Buffalo. Dr. Sutton, a Rho Chi member, worked as a retail pharmacist in Harvard Square for a year before returning to school. After graduate school he joined the General Pharmaceutics Group, Ciba-Geigy (Ardsley, NY), for several years. In the mid-eighties,  Dr. Sutton and his family moved to Lawrence, KS for a 6 year period and he worked at INTERx Research Corporation, (founded by Takeru Higuchi, the 'father of physical pharmacy') a subsidary of  Merck & Co. 

In 1992-2009, Dr. Sutton joined the Groton Lab of Pfizer in what was then called the Pharmaceutical R&D Department. In 2009, when he embarked on his second career of teaching at the College of Pharmacy at the University of New England, Portland, Maine.

Dr. Sutton has been active in the professional organization, the American Association of Pharmaceutical Scientists (AAPS). For example, he founded the AAPS Oral Absorption Focus Group in 1995, and was a founding member of both the Hudson Valley and Kansas City Pharmaceutics Discussion Groups. He served as General Chair of the AAPS Midwest Regional Meeting, as well as organized multiple national meeting symposia over the years. He is also a member of the editorial board of the AAPS PharmSciTech and The AAPS Journal. Dr. Sutton is a research Fellow of the American Association of Pharmaceutical Scientists, and a Fellow of the American Academy of Veterinary Pharmacology and Therapeutics. Dr. Sutton has held an adjunct professor appointment at the University of Connecticut School of Pharmacy (UCONN); and a visiting scientist status at MCPHS, College of Pharmacy, and SUNY at Buffalo, College of Pharmacy. Previously, he also held an adjunct professor appointment at the School of Pharmaceutical Sciences, Kansas University (KU), Lawrence, and the School of Pharmacy, University of Missouri-Kansas City (UMKC) and at UCONN. At KU and UMKC, he served as a member on graduate students' research committees. 

Dr. Sutton has authored or co-authored almost 130 book chapters, abstracts of work in progress, invited presentations and patents. 

His personal interests include SCUBA, fine woodworking, and trying to grow tomatoes. Dr. Sutton met his wife, Kimberly, a registered pharmacist, in graduate school and has 3 children: Brenton, an employee of Origene, Inc. (Rockville, MD), Alexander, a Post-Doc at Brandeis and Katherine, who recently earned her BS degree in Ecology & Environmental Science at Murdoch University, Australia.

Education

PhD

State University of New York at Buffalo

BS

Massachusetts College of Pharmacy

Board Certifications and Licenses

Pharmacy: MA, NY

Clinical Affiliations

Maine

Research

Current Research

Dr. Sutton recently led an interdisciplinary group of scientists to draft a report on estimating product bioequivalence for highly variable veterinary drugs: Claxton, R., Endrenyi, L., Lucas, A., Martinez, M. & Sutton, S. Estimating product bioequivalence for highly variable veterinary drugs. J vet Pharmacol Therap,35:11-16, 2012.

Along with Phillip Smith, Dr. Sutton recently also completed the chapter 'Animals Suitable for Modeling Controlled Release' for the book: 'Oral Controlled Release', Clive Wilson, Brigitte Skalsky & Patrick Crowley (eds), Controlled Release Society, The Springer Publishing Company, New York 2011.

Dr. Sutton recently also completed a collaborative effort with the Dean on a subject they have both published in the past: Shah, J., S.C. Sutton, S. Way, G. Brazeau: Chapter 50. Parenteral Formulations: Local Injection Site Reaction and Muscle Tolerance., In: Encyclopedia of Pharmaceutical Science and Technology, 4th Edition, Informa Healthcare London (expected print date: 2012).

Dr. Sutton has recently completed working on two chapters for the book 'Animal Health Drug Delivery', M. Rathbone (Ed), CRS Books, St. Paul, MN (expected print date: 2012). These are 'Anatomy And Physiology Of The Companion Animal' and 'Biopharmaceutics And Veterinary Drug Delivery'.

Dr. Sutton will participate as a panelist at the 2012 AAPS Annual Meeting and Exposition to be held October 14-18, in Chicago, IL at the McCormick Place: Preclinical ADME Models and Simulation Tools: Successful Integration and Optimized Clinical Outcome (#246).

Research Interests

Determine the mechanisms by which persistent organic pollutants (POPs)associated with micron-sized fragments of ocean-sourced plastic find their way into living organisms.

Investigate the nuances of weakly basic drugs (WBD) that predispose them to precipitate in the intestine after oral administration. The goals of this research are 1) to predict in silico whether a WBD will precipitate in vivo

Selected Publications

1.Sutton, S.C. Companion animal physiology and dosage form performance ADDR 56: 1383-1398, 2004.

2.Sutton SC, Hu MS. An Automated Process for Building Reliable Optimal IVIVC Models Based on Monte Carlo Simulations. The AAPS Journal 2006;8:1-13.

3.Sutton, S. C., L. A. F. Evans, J. H. Fortner, J. M. McCarthy and K. A. Norton. "Dog Colonoscopy Model For Predicting Human Colon Absorption." Pharm Res, 23: 1554-1563, 2006.

4.Sagawa, K., F. Li, R. Liese, and S. C. Sutton, Fed and fasted gastric pH and gastric residence time in conscious beagle dogs. Journal of Pharmaceutical Sciences, 2009. 98(7): p. 2494-2500.

5.Sutton, S.C., Role of Physiological Intestinal Water in Oral Absorption. The AAPS Journal, 2009. 11(2): p. 277-285

6.Steven C. Sutton, The Use of Gastrointestinal Intubation Studies For Controlled Release Development. British Journal of Clinical Pharmacology, 2009. 68(3): p. 342-354.

7.Sutton, SC, MTS Rinaldi and K Vukovinsky: Comparison of the Gravimetric, Phenol Red and 14C-PEG-3350 Methods to Determine Water Absorption in the Rat Single Pass Intestinal Perfusion Model. AAPS Pharm Sci, 3 (3) article 25, 2001, pp1-7. (http://www.pharmsci.org/scientificjournals/pharmsci/journal/01_25.html).

8.Sutton, SC, MTS Rinaldi JM McCarthy and KE Vukovinsky: A Statistical Method for the Determination of Absorption Rate Constant Estimated Using the Rat Single Pass Intestinal Perfusion Model and Multiple Linear Regression. J Pharm Sci 91:1046-1053, 2002.

9.Waterman, K.C. and S.C. Sutton, A computational model for particle size influence on drug absorption during controlled-release colonic delivery. Journal of Controlled Release, 2003. 86(2-3): p. 293-304.

Other Scholarly Activity

32. Sagawa, K. & Sutton, S. C, (2006). Gastrointestinal physiology: species differences. 2nd Joint AAPS/AAVPT/CRS workshop 2006 "The Challenges of Delivering Drugs to Animals", San Antonio, TX, October 27-29, 2006.
33. GI Transit Times in Animals. 2n

Funded Grants

2010-11 ($1,000) Investigation into the effect of physicochemical properties of molecules on their precipitation in the human GI tract, Pfizer, Groton, CT.

2011 ($10,000) Unrestricted research on the effect of physicochemical properties of molecules on their precipitation in the human GI tract, Boehringer Ingelheim, Danbury, CT.

Invited Plenary Presentation

S. C. Sutton: The Use of Gastrointestinal Intubation Studies For Controlled Release Development, presented at the Drug Metabolism Discussion Group (a Simcyp Company Consortium), in Sheffield, UK, February, 2010.

S. C. Sutton: Use of GastroPlusTM models in veterinary research and development, Presented at the Controlled Release Society National Meeting in Portland, OR, July 12, 2010.

S.C. Sutton: Counterfeits, 6th Global Conference on Pharmaceutical AntiCounterfeiting, London, May 12, 2011.

S.C. Sutton: Counterfeits: A Global Problem Come Home, 125th Celebration, State University of New York at Buffalo, School of Pharmacy and Pharmaceutical Sciences, Keynote Speaker, Sept 2011.

Steven (Steev) C Sutton

,

BS Pharmacy, PhD Pharmaceutical Sciences

Chair; Associate Professor; A.A.P.S. Fellow

Pharmacy Building
320

ssutton1@une.edu

(207) 221-4173