The Interprofessional Simulation and Innovation Center has a presence on UNE's Portland and Biddeford campuses. In Portland, it occupies two floors in the Blewett Science Building, adjacent to skills laboratories and classrooms. In Biddeford, it has dedicated space in the Harold Alfond Forum. 

The center offers three simulation labs with adjoining fully-equipped control rooms, a task training lab and a debriefing classroom. The program also has dedicated space for staff offices, welcoming visitors, and storage. All of the labs are flexible and fully equipped for audiovisual recording, presentations and debriefing.