Dr. Ian Meng received his ScB in Neuroscience at Brown University in 1991 and went on to complete his PhD with Dr. David Bereiter at Brown in the Department of Biology and Medicine, Section of Physiology and Neurobiology in 1997. As a graduate student, Dr. Meng characterized corneal sensitive neurons within the spinal trigeminal nucleus, examining the spatial and electrophysiological properties with which corneal stimulation is encoded. Following completion of his PhD, Dr. Meng worked as a postdoctoral fellow with Dr. Howard Fields in the Department of Neurology at the University of California, San Francisco (UCSF). His postdoctoral studies focused on pain modulatory systems, in particular the circuits mediating the analgesic properties of cannabinoids. Dr. Meng joined the University of New England in 2003 where he is currently a professor of Biomedical Sciences and the director of the COBRE Center for the Study of Pain and Sensory Function.
Department of Neurology
University of California, San Francisco
Neuroscience; pain; headache; ocular pain; addiction.
The overarching goal of Dr. MengÕs research is to understand trigeminal sensory processing underlying headache and ocular pain and homeostasis, with an emphasis on two conditions: medication overuse headache and dry eye syndrome. Dr. MengÕs lab is currently investigating sensory neurons that regulate tearing and ocular pain under both normal and pathological conditions such as dry eye. In studies relevant to headache, Dr. MengÕs research aims to understand the neuroplastic changes induced by the chronic use of analgesics, as such treatments have been shown to transform episodic migraines into chronic daily headache.
Ocular pain; migraine headache; medication overuse headache; transformation of migraine headache to chronic daily headache.
Okada-Ogawa A, Porreca F, Meng ID (2009) Sustained morphine-induced sensitization and loss of diffuse noxious inhibitory controls in dura-sensitive medullary dorsal horn neurons. J Neurosci. 29: 15828-15835.
De Felice M, Ossipov MH, Wang R, Lai J, Chichorro JG, Meng I, Dodick DW, Vanderah TW, Dussor G, Porreca F (2010) Triptan-induced latent sensitization: A possible basis for medication overuse headache. Annals of Neurology. 67(3): 325-37.
De Felice M, Ossipov MH, Wang R, Dussor G, Lai J, Meng ID, Chichorro J, Andrews JS, Rakhit S, Maddaford S, Dodick D Porreca F (2010) Triptan-induced enhancement of neuronal nitric oxide synthase in trigeminal ganglion dural afferents underlies increased responsiveness to potential migraine triggers. Brain. 133(Pt 8): 2475-88.
Hirata H, Meng ID (2010) Cold-sensitive corneal afferents respond to a variety of ocular stimuli central to tear production: implications for dry eye disease. Invest Ophthalmol Vis Sci. 51(8):3969-76.
Okada-Ogawa A, Kurose M, Meng ID (2010) Attenuation of cannabinoid-induced inhibition of medullary dorsal horn neurons by a kappa-opioid receptor antagonist. Brain Res. 1359: 81-9.
Reynolds J, Bilsky EJ, Meng ID (2011) Selective ablation of mu-opioid receptor expressing neurons in the rostral ventromedial medulla attenuates stress-induced mechanical hypersensitivity. Life Sci. 89(9-10): 313-9.
Robbins A, Schmitt D, Winterson BJ, Meng ID (2012) Chronic morphine increases Fos-positive neurons after concurrent cornea and tail stimulation. Headache. 52 (2): 262-73.
Robbins A, Kurose M, Winterson BJ, Meng ID (2012) Menthol activation of corneal cool cells induces TRPM8-mediated lacrimation but not nociceptive responses in rodents. Invest Ophtahalmol Vis Sci. 53(11): 7034-42.
Meng (Co-Investigator), Mechanism of Medication Overuse Headache and Chronic Migraine Pain, NIH/NINDS, Period of funding: 4/1/10-3/31/15.
Meng (Principal Investigator), Dry-responsive corneal afferents, TRPM8, and regulation of tears, NIH/NEI, Period of Funding 8/1/11-7/30/14.
Meng (Principal Investigator), Interdisciplinary Center of Excellence for the Study of Pain and Sensory Function, NIH/NCRR, Period of Funding 8/15/2012-5/31/2017.