Olgun Guvench joined the UNE College of Pharmacy as Assistant Professor in the Department of Pharmaceutical Sciences in July of 2009. Before joining UNE, Dr. Guvench was a National Institutes of Health Kirschstein Postdoctoral Fellow at the University of Maryland, where he trained in biomolecular simulation and structure-based discovery/design, including developing new atomic-resolution models for simulating carbohydrates. Dr. Guvench teaches biomedical sciences to Pharm.D. students and pursues research in the field of biomolecular simulation, with a focus on proteoglycans and protein-carbohydrate interactions.
The Scripps Research Institute
NIH Kirschstein Postdoctoral Fellowship
University of Maryland
Recent systems under study include:
-Proteoglycan core proteins and glycosaminoglycans
-Molecular modeling of proteoglycans
-Protein-carbohydrate interactions in molecular recognition and signaling
Faller CE, Guvench O. Sulfation and cation effects on the conformational properties of the glycan backbone of chondroitin sulfate disaccharides. J Phys Chem B. 2015;119(20):6063-73.
Faller CE, Guvench O. Terminal sialic acids on CD44 N-glycans can block hyaluronan binding by forming competing intramolecular contacts with arginine sidechains. Proteins. 2014;82(11):3079-89.
Du X, Zhou J, Guvench O, Sangiorgi FO, Li X, Zhou N, Xu B. Supramolecular Assemblies of A Conjugate of Nucleobase, Amino Acids, and Saccharide Act as Agonists for Proliferation of Embryonic Stem Cells and Development of Zygotes. Bioconjug Chem. 2014 Jun 18;25(6):1031-5.
Favreau AJ, Faller CE, Guvench O. CD44 Receptor Unfolding Enhances Binding by Freeing Basic Amino Acids to Contact Carbohydrate Ligand. Biophys J. 2013 Sep 3;105(5):1217-26.
Yu B, Liu W, Yu WM, Loh ML, Alter S, Guvench O, Mackerell AD Jr, Tang LD, Qu CK. Targeting Protein Tyrosine Phosphatase SHP2 for the Treatment of PTPN11-Associated Malignancies. Mol Cancer Ther. 2013 Sep;12(9):1738-48.
Faller CE, Reilly KA, Hills RD, Jr., Guvench O. Peptide backbone sampling convergence with the adaptive biasing force algorithm. J Phys Chem B. 2013;117(2):518-26.
Mallajosyula SS, Guvench O, Hatcher E, Mackerell AD, Jr. CHARMM Additive All-Atom Force Field for Phosphate and Sulfate Linked to Carbohydrates. J Chem Theory Comput. 2012;8(2):759-76.
Foster TJ, Mackerell AD, Jr., Guvench O. Balancing target flexibility and target denaturation in computational fragment-based inhibitor discovery. J Comput Chem. 2012;33(23):1880-91.
“Atomic resolution modeling of proteoglycans”
5/1/2015 – 4/30/2020