Lei Lei

Professional Experience

Assistant Professor, Department of Biology and Center for Excellence in the Neurosciences, University of New England

Assistant Professor, School of Life Sciences, Arizona State University

Instructor, University of Texas Southwestern Medical Center at Dallas

 

Awards and Honors

Ruth L. Kirschstein National Research Service Award Postdoctoral Fellowship (F32), NINDS, NIH

Other Professional Activities

Member, Society for Neuroscience

Teaching Experience

BIO106: BIO II - Cellular/Molecular Biology

BIO315: Developmental Biology

BIO370: Cell Biology

BIO450: BIO Topics - Developmental Neurobiology

Service Experience

Director, Biology Honors Program

 

Education

Ph.D.

Department of Biochemistry, Michigan State University, Michigan

1998

B.S.

Department of Biology, Wuhan University, China

1991

Post-Doctoral Training

Postdoctoral Fellow

University of Texas Southwestern Medical Center, laboratory of Dr. Luis F. Parada

Dallas

Texas

Clinical Affiliations

Maine

Expertise

neuroscience

developmental biology

molecular biology

sensory neurons

neural stem cells

transgenic mice.

Research

Research Interests

sensory neuron and pain

Selected Publications

1. Lin, L., Lee, V., Wang, Y., Lin, J., Sock, E., Wegner, M., and Lei, L. (2011). Sox11 regulates survival and axonal growth of embryonic sensory neurons. Developmental Dynamics 240, 52-64.

2. Romero, M., Lin, L., Lush, M., Lei, L., Parada, L.F., and Zhu, Y. (2007).  Deletion of Nf1 in neurons induces increased axon collateral branching after dorsal root injury. Journal of Neuroscience 27, 2124-2134. 

3. Lei, L.*, and Parada, L.F. (2007). Transcriptional regulation of Trk family neurotrophin receptors (Invited review).  Cellular and Molecular Life Sciences 64, 522-532.  * Corresponding author.

4. Lei, L., Zhou, J., Lin, L., and Parada, L.F. (2006).  Brn3a and Klf7 cooperate to control TrkA expression in sensory neurons.  Developmental Biology 300, 758-769. 

5. Lei, L., Laub, F., Lush, M., Romero, M., Zhou, J., Luikart, B., Klesse, L., Ramirez, F., and Parada, L.F. (2005).  The zinc finger transcription factor Klf7 is required for TrkA gene expression and development of nociceptive sensory neurons. Genes & Development 19, 1354-1364.

6. Laub, F., Lei, L., Sumiyoshi, H., Kajimura, D., Dragomir, C., Smaldone, S., Puche, A.C., Petros, T.J., Mason, C., Parada, L.F., and Ramirez, F. (2005).  Transcription factor KLF7 is important for neuronal morphogenesis in selected regions of the nerv¬ous system. Molecular and Cellular Biology 25, 5699-5711.

7. Ma, L., Lei, L., Eng, S.R., Turner, E., and Parada, L.F. (2003).  Brn3a regulation of TrkA/NGF receptor expression in developing sensory neurons.  Development 130, 3525-3534.

8. Lei, L., Ma, L., Nef, S., Thai, T., and Parada, L.F. (2001). mKlf7, a potential transcriptional regulator of trkA nerve growth factor receptor expression in sensory and sympathetic neurons.  Development 128, 1147-1158.

9. Lei, L., Ren, D., and Burton, Z.F. (1999). The RAP74 subunit of human transcription factor IIF has similar roles in initiation and elongation. Molecular and Cellular Biology 19, 8372-8382.

10. Ren, D., Lei, L., and Burton, Z.F. (1999).  A region within the RAP74 subunit of human transcription factor IIF is critical for initiation but dispensable for complex assembly.  Molecular and Cellular Biology 19, 7377-7387. 

11. Lei, L., Ren, D., Finkelstein, A., and Burton, Z.F. (1998).  Functions of the N- and C-terminal domains of human RAP74 in initiation, elongation, and recycling of RNA polymerase II.  Molecular and Cellular Biology 18, 2130-2142.

12. Wang, B.Q., Lei, L., and Burton, Z.F. (1994).  Importance of codon preference for production of human RAP74 and reconstitution of the RAP30/74 complex.  Protein Expression  and Purification 5, 476-485.

Other Scholarly Activity

INVITED SEMINARS

1. The 31st Annual Meeting of the Society for Neuroscience. November 10-15, 2001; San Diego, California.

2. 1st Annual Neuroscience Symposium cosponsored by the Barrow Neurological Institute and Arizona State Univers

Funded Grants

Ruth L. Kirschstein National Research Service Award Postdoctoral Fellowship (F32), NINDS, NIH. Role: PI.

This proposal focuses on the identification and characterization of transcription factors that bind the mouse TrkA minimal enhancer.

The ASU/MCA Partnership for Collaborative Research Seed Grant Program. Role: PI.

This proposal focuses on the generation and characterization of an animal model to study the function of adult neural stem cells.

Arizona Biomedical Research Commission. Role: PI.

This study focuses on the role of a key transcription factor in regulating cortical development including proliferation and migration.

Lei Lei

Lei Lei

,

Ph.D.

Assistant Professor

Morgane Hall
9

LLei@une.edu

(207) 602-2353