Neuroscience and Pain

Chronic pain affects more than 100 million Americans per year, resulting in extraordinary personal and societal costs in diminished quality of life, lost productivity and health care consumption. For many of these patients, available treatments are inadequate, creating a dire need for the development of more effective treatments. The transition from acute to chronic pain is driven by changes in the processing of sensory information in both the peripheral and central nervous system, a form of maladaptive plasticity that can be considered a separate disease entity in its own right. Research programs at UNECOM on the neurobiology of pain use molecular, physiological, pharmacological and behavioral approaches to understand the mechanisms that underlie the development of chronic pain and to develop new therapeutic interventions. 

Faculty

Ling Cao

Ling Cao

M.D., Ph.D.

Associate Professor

Graduate Faculty for the Graduate Studies of the Biomedical Sciences and Engineer (GSBSE) program, The Graduate School, University of Maine, ME

(207) 602-2213

lcao@une.edu

Pickus Center
207

Expertise

Neuroimmunology and immunotoxicology.

Associate Professor

(207) 602-2415

fdaly@une.edu

Stella Maris
428

Dr. Frank Daly has focused on vertebrate retinal biology and is currently an associate professor of biomedical science at the University of New England College of Osteopathic Medicine. Dr. Daly received his Ph.D. in Anatomy and Neurobiology from Boston University and subsequently held a research associate position at the Howard Hughes Medical Institute in Boston. Dr. Daly has research interest in the developing nervous system, using immuno-histochemistry and other molecular techniques to investigate melanopsin in the retina of the Nassau Grouper, the... Read More

Expertise

Vertebrate Retina Anatomy

Physiology histology

Immunocytochemistry

In Suit Hybridization

Tamara King

Associate Professor

(207) 602-2981

tking6@une.edu

Stella Maris
308A

Research interests center around mechanistic analysis of pain, with a specific focus on cancer-induced bone pain, osteoarthritis induced joint pain and chronic pain induced by nerve injury (neuropathic pain). An important aspect of my research is using approaches that allow for mechanistic evaluation of affective/motivational aspects of pain and pain relief in the preclinical setting. Such an approach will lead to the discovery of molecules that can effectively ameliorate ongoing pain across various preclinical models of pain, including cancer induced bone... Read More

Expertise

Research program on mechanisms underlying chronic pain

Derek Molliver

Associate Professor

(207) 602-2221

dmolliver@une.edu

Stella Maris
203

Derek Molliver received his B.A. from Williams College in 1988 and went on to complete his PhD in Neuroscience at Washington University in St. Louis in 1997, studying the role of neurotrophic factors in the development of peripheral sensory neuron identity with Dr. William Snider. He then took a postdoctoral fellowship with Dr. Ed McCleskey at the Vollum Institute of Oregon Health and Science University, examining the function of purinergic G protein-coupled receptors (GPCRs) in adult nociceptive sensory neurons. After two... Read More

Expertise

neuroscience

cell and molecular biology

Neurobiology of acute and pathological pain including neuropathic pain

G protein coupled receptors

Proteomics

Kerry Tucker

Associate Professor

(207) 602-2512

ktucker2@une.edu

I come from the North Shore of Massachusetts, and I studied biochemistry at Harvard College, starting my research career purifying clathrin proteins from sheep brain at Harvard Medical School. I continued my studies as a graduate student at the Massachusetts Institute of Technology, in Cambridge, MA where I studied the role of DNA methylation in the development of the mouse, working in the lab of Rudolf Jaenisch. I then switched to developmental neuroscience as a postdoctoral fellow in the laboratory... Read More

Expertise

Histology

Embryology

Genetics

neuroscience

Macroscopic anatomy

molecular biology