Atlantic Union College
Department of Neurobiology
Harvard Medical School
Dr. Ganter's laboratory is investigating the mechanisms of nociception using the powerful genetic toolkit of the fruit fly Drosophila melanogaster. Pain affects all of our lives in some way, yet we know only a little of how pain works and how to block it. The tiny fly might be able to lead us to the next generation of improved medications for pain in humans.
Neurobiology of nociception.
Follansbee TL*, Gjelsvik KJ*, Brann CL*, McParland AL*, Longhurst CA*, Galko MJ, Ganter GK. Nociceptive Sensitization Requires BMP Signaling via the Canonical SMAD Pathway. J Neurosci. 2017 Aug 30;37(35):8524-8533
McParland AL*, Follansbee TL*, Vesenka GD, Panaitiu AE*, Ganter GK. Steroid
receptor isoform expression in Drosophila nociceptor neurons is required for
normal dendritic arbor and sensitivity. PLoS One. 2015 Oct 23;10(10):e0140785
McParland AL*, Follansbee TL*, Ganter GK. Measurement of larval activity in the
Drosophila activity monitor. J Vis Exp. 2015 Apr 30;(98):e52684
Ganter GK, Desilets JB, Davis-Knowlton JA, Panaitiu AE*, Sweezy M, Sungail J, Tan LCH*, Adams AM*, Fisher EA*, O'Brien JRM*, Kincaid KM*, Heinrich R. Drosophila female precopulatory behavior is modulated by ecdysteroids (2012) Journal of Insect Physiology, 58 (3): 413-419
Ganter GK, Panaitiu AE*, Desilets JB*, Davis-Heim JA, Fisher EA*, Tan LCH*, Heinrich R, Buchanan EB*, Brooks KM*, Kenney MT*, Verde MG*, Downey J*, Adams AM*, Grenier JS*, Maddula S*, Shah P*, Kincaid KM*, O'Brien JRM.* Drosophila male courtship behavior is modulated by ecdysteroids (2011) Journal of Insect Physiology, 57 (9): 1179-1184
Ganter GK, Walton KL*, Merriman JO*, Salmon MV*, Brooks KM*, Maddula S*, Kravitz EA. Increased male-male courtship in ecdysone receptor deficient adult flies (2007) Behavior Genetics, 37 (3): 507-512. (Accepted 12/27/2006, published 1/20/07)
* indicates undergraduate co-author
2017-2018. Pilot Project Leader of National Institutes of Health - Centers Of Biomedical Research Excellence award: “Phase 2: Interdisciplinary center of excellence for the study of pain and sensory function” (total: $10M) Principal Investigator Ian Meng. (1 year: $50K).
2015-2018. Principal Investigator of National Institutes of Health - National Institute of Neurological Disorders and Stroke: “Characterization of the BMP signaling pathways that produce nociceptor sensitization in Drosophila. (3 years: $443K).
2012-2017. Project Leader of National Institutes of Health - Centers Of Biomedical Research Excellence award: “Phase 1: Interdisciplinary center of excellence for the study of pain and sensory function” (total: $10M) Principal Investigator Ian Meng. (5 years: $1M).
2012. Co-Investigator of National Science Foundation – Major Research Instrumentation award: MRI: “Acquisition of a Scanning Spectral Confocal Microscope for Multidisciplinary Research, Teaching and Outreach” ($434K).
2008-2011. Principal Investigator of National Institutes of Health – National Institute of General Medical Sciences, “Ecdysone modulation of sexual behavior in Drosophila melanogaster “(3 years:$208K).