Ron Hills

Ron Hills is Associate Professor of Pharmaceutical Sciences at the University of New England in Portland, Maine. Since joining the College of Pharmacy in 2010, he has taught courses in biochemistry, medicinal chemistry, computer programming and pharmacology. Dr. Hills' research specialty is in computer modeling and his personal interests include nutrition, which he often incorporates in his teaching.

Students working in Dr. Hills' laboratory use novel simulation methods to study the molecular biophysics of membrane protein systems relevant to drugs and disease. Topics of focus include the role of lipid-protein interactions in cell function and acquired multidrug resistance associated with ABC transport proteins.

facebook.com/ProfessorHills

Education

Ph.D., Biophysics

Scripps Research Institute

2008

B.S., Summa Cum Laude, Biochemistry

Florida State University

2003

Post-Doctoral Training

NIH Kirschstein Postdoctoral Research Fellow, 2009-2010

University of Utah and University of Chicago

Expertise

molecular dynamics simulation

protein structure and function

multiscale modeling

Research

Research Interests

  • Development of multiscale and coarse-grained models for protein assemblies
  • Lipid-protein membrane interactions and protein conformational change
  • Cellular multidrug resistance mediated by ABC transporters

Selected Publications

Hills Jr., R.D. 2018. Refining amino acid hydrophobicity for dynamics simulation of membrane proteins. PeerJ 6:e4230.

Fosso-Tande, J., C. Black, S.G. Aller, L. Lu and R.D. Hills Jr. 2017. Simulation of lipid-protein interactions with the CgProt force field. AIMS Mol. Sci. 4:352-69.

Hills Jr., R.D. and N. McGlinchey. 2016. Model parameters for simulation of physiological lipids. J. Comput. Chem. 37:1112-18. Featured on inside journal cover. 

Ward, A.B., O. Guvench and R.D. Hills Jr. 2012. Coarse grain lipid-protein molecular interactions and diffusion with MsbA flippase. Proteins 80:2178-90. Featured on Journal Cover.

Funded Grants

NSF 13-510 proposal no. 1516826 Hills (PI) 9/1/15 – 8/31/18
RUI: Multiscale models for ABC transporter molecular dynamics
Goal: Dissect lipid-protein molecular interactions and mutual adaptation in multidrug exporters.
Role: PI. Total Cost: $374,885

NIH R15 AREA GM099022 Guvench (PI) 9/1/11 – 8/31/15
Molecular Mechanism of Flexible Carbohydrate-Protein Interaction in CD44
Goal: Identify molecular-level interactions governing flexible CD44:hyaluronan binding using computer simulations.
Role: Co-Investigator (5% Effort). Total Cost: $352,480 (one year no-cost extension)

Ronald Hills

Ron Hills

,

Ph.D.

Associate Professor

Portland Campus

Pharmacy Building
305

rhills@une.edu

(207) 221-4049

On Campus

Eligible for Student Opportunities