Steven (Steev) C. Sutton, B.S. Pharmacy, Ph.D., FAAPS
Associate Professor, Department of Pharmaceutical Sciences and Administration
Location
Hi! I am Dr. Steven 'Steev' C. Sutton. I earned my B.S. Pharmacy Cum Laude from Massachusetts College of Pharmacy, Boston, where I was inducted into Rho Chi. I worked as a retail pharmacist in Harvard Square and Lowell, MA for about a year before returning to school. I met the love of my life in the School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo. About the same time I earned my Ph.D. in Pharmaceutical Sciences, our first son was born, and I joined the General Pharmaceutics Group, CIBA-Geigy (now Novartis). A little later, we had our second son, and we moved to Lawrence, KS (go Jayhawks!) and worked at INTERx Research Corporation (founded by Takeru Higuchi, the 'father of physical pharmacy', and a subsidiary of Merck & Co). Soon after our daughter was born we moved back to New England and I joined Pfizer Labs in Groton, CT in what was then called the Pharmaceutical R&D Department. In 2009, I became an inaugural faculty at the College of Pharmacy at the University of New England, Portland, Maine. My personal interests include hiking, fine woodworking and gardening.
Credentials
Education
Expertise
Cell culture
Genetics
Pharmaceutics
Pharmacokinetics
Physiology
Board Certifications and Licenses
Research
Current research
A Farnham, SH Stafford, SC Sutton: Impact of Dose on Amount of Polystyrene Nanoparticles Translocated Across Caco-2 Cell Monolayers, AAPS NERDG Annual Meeting, Farmington, CT, April 20, 2017.
A Farnham, SC Sutton: An HT29 Cell Monolayer Model to Investigate the Cumulative Genotoxic Effects of POPs and Nanoparticles, AAPS NERDG Annual Meeting, Farmington, CT. April 19, 2016.
Duong, S. and S. C. Sutton: Predicting the Physiologically Relevant Precipitation Rate of Weakly Basic Drugs Using Potentiometric Titration. AAPS National Meeting, San Antonio, TX, AAPS, 2013.
Selected publications
Jabor, Z. and S. C. Sutton (2023). "Effects of Digestion, Cell Culture Media, and Mucous on the Physical Properties, Cellular Effects, and Translocation of Polystyrene and Polymethacrylate Nanoparticles." Toxics 11(8): 708-720.
Canham, S., S. C. Sutton. Effects of in vitro digestion on the impact of plastic nanoparticles in an in vitro intestinal model. SoP Dean’s Research Day, UNE, Portland, ME 1 September 2021.
Kachrani, H., A. Farnham, D. Brazeau, S. C. Sutton (2019). Genetic evidence for the impact of inflammation caused by orally ingested nanoparticles of plastic (likely food contaminants) on an in vitro model of the gut. Maine Pharmacy Association Fall Convention, Portland, ME 14 September 2019.
Hurley, B., Farnham, A., Brazeau, D., Sutton, S.C. (2019). Determining Whether Gene Toxicity from Acute Exposure of Plastic Nanoparticles and the Polycyclic Aromatic Hydrocarbon – Benzo[a]pyrene are Additive. UNECOM Research Forum September 2018.
Lincoln, R., S. C. Sutton (2018). The effects of B[a]P on an in vitro model of the human GI immune system. Maine Pharmacy Association Fall Convention, Portland, ME 22 September 2018.
Other scholarly activity
Sutton, S. C. (2017). Chapter 3. Drug Administration and Drug Absorption. Basic Pharmacokinetics and Pharmacodynamics. S. Rosenbaum. Hoboken, NJ, Wiley: 35-70.
Sutton, S. C. (2017). Chapter 9. Pharmacokinetics of Extravascular Drug Administration. Basic Pharmacokinetics and Pharmacodynamics. S. Rosenbaum. Hoboken, NJ, Wiley: 201-224
Sutton, S.C (2013) Chapter 6: “Biopharmaceutics and veterinary drug delivery”, In: Animal Health Drug Delivery, Michael Rathbone (Ed), Controlled Release Society, The Springer Publishing Company, New York
Sutton, S.C (2013) Chapter 4: “Anatomy and physiology of the companion animal”, In: Animal Health Drug Delivery, Michael Rathbone (Ed), Controlled Release Society, The Springer Publishing Company, New York
Jaymin Shah, Steve Sutton, Susan Way, Gayle Brazeau (2013) “Parenteral Formulations: Local Injection Site Reaction and Muscle Tolerance”, In: Encyclopedia of Pharmaceutical Technology Third Edition, James Swarbrick (ed) Informa Healthcare USA, Inc., New York
Sutton, S.C., P. Smith (2011) Chapter 3. Animals Suitable for Modeling Controlled Release, In: “Oral Controlled Release”, Clive Wilson, Brigitte Skalsky & Patrick Crowley (eds), Controlled Release Society, The Springer Publishing Company, New York.
Funded grants
Maine INBRE Core Access grant: Effect of nanoparticles on the barrier integrity of an in vitro cell-based intestinal model. 2023-24.
UNE CoP Dean’s Summer Fellowship: Plastic nanoparticles on an in vitro model of the inflamed intestine. Carmella St Pierre, Pharm D student, Class of 2025. 2022.
Invited plenary presentation
Sutton, SC. Challenges When Working with Different Animal Species. USP Workshop on In vitro Testing for Meeting Future Challenges for Veterinary Dosage Forms, March 14–15, 2016 USP Meetings Center, Rockville, Maryland.
Sutton, SC. Interspecies intestinal differences and impact on oral dosage forms for animal health” to be presented at the joint CRS/AAPS workshop “Animal Health Drug R&D: Formulation, Delivery and Development to Market”, November 1-2, 2014, in San Diego
Sutton, SC. The anatomy & physiology of interspecies’ biopharmaceutics, presented at the “Interspecies clinical pharmacology dosing concepts” mini-symposia, at the 2014 Annual Meeting of the Controlled Release Society, July 13-16, 2014, in Chicago
Sutton, SC. Predictive Animal Models for Assessing Long-Acting Formulations for Human and Animal Health, presented at the Inaugural Controlled and Modified Drug Release Conference in Philadelphia, PA on May 7-8, 201
Sutton, SC. Critical Features of Solubility and Permeability that can Limit the Food Effect, presented at the 2nd annual Drug Formulation & Bioavailability – West Coast, in San Diego, CA, on June 2-3, 2014
Sutton, S. C.: Biopharmaceutics and Pharmacokinetics of the Food Effect, presented at the Roundtable: When Food Impacts Oral Drug Exposure: The Nature and Study of the Food Effect. AAPS National Meeting, San Antonio, Nov., 2013.
Sutton SC. Utilizing in silico, in vitro and preclinical methods to optimize your clinical prediction from biopharmaceutic modeling. ExlPharma’s 2nd Enhancing Drug Bioavailability and Solubility Conference, Boston, MA January, 2013
Research interests
Determine the impact of chronic low-level orally ingested "forever" chemicals and nano plastic particles on the immune system of the intestines.