May 18, 2019
Diana Goode, Ph.D., postdoctoral fellow, and Derek Molliver, Ph.D., associate professor of Biomedical Sciences, recently had their research published in the Journal of Molecular and Cellular Biochemistry, a peer-reviewed scientific journal covering research in cellular biology and biochemistry.
Their article, titled “Phospho-substrate profiling of Epac-dependent protein kinase C activity,” outlines a new approach developed by the lab to identify the targets of a signaling protein called Epac.
Epac controls a wide range of biological activities and is expressed in many different tissues throughout the body. It has been implicated in diverse disease states, including cardiac enlargement, cancer and chronic pain.
To date, it has been difficult to identify which proteins are directly regulated by Epac.
Goode and Molliver plan to use this new approach to identify outcomes downstream of Epac activation. In the future, such outcomes can possibly be selectively targeted to treat these and other disease states.