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Ling Cao

Ling Cao, M.D., Ph.D.

Professor, Immunology

Location

Pickus Center for Biomedical Research 207
Biddeford Campus
On campus
Eligible for Student Opportunities

Credentials

Education

MD
Beijing Medical University
1997
PhD
SUNY Albany
2002

Post-Doctoral Training

Post-Doctoral Training, Neuroimmunology
Dartmouth College (Lebanon, New Hampshire)

Post-Doctoral Training, Psychoneuroimmunology
University of Rochester (Rochester, New York)

Research

Current research

1. Role of microglial CD137L in peripheral nerve injry-induced neuropathic pain and nerve regeneration

2. Neuroimmune mechanisms in murine AIDS viral infection induced peripheral neuropathy - roles of CGRP on  glial responses upon infection.

3. Effects of morphine on murine AIDS -induced neurocognitive disorders.

4. Roles of CD4 T cells, and microglial CD40 in spinal nerve L5 transection-induced neuropathic pain

5. Clinical and education research with Mercy Pain Center on various chronic pain management related topics.

Selected publications

Please view the complete list of our publications through the following link:
http://www.ncbi.nlm.nih.gov/myncbi/ling.cao.1/bibliography/46382587/public/?sort=date&direction=ascending

  • L. Cao, L. Fei, T. T. Chang, and J. A. DeLeo. 2007.  Further induction of IL-1beta by IL-4 in LPS-treated mixed glial cultures.  Journal of Neurochemistry 102(2), 408-419.
  • C. A. Hudson, G. P. Christophi, L. Cao, R. C. Gruber and P. T. Massa. 2007.  Regulation of avoidant behaviors and pain by the anti-inflammatory tyrosine phosphatase SHP-1.  Neuron Glia Biology 2 (4), 235-246.
  • I. D. Meng and L. Cao. 2007.  From migraine to chronic daily headache: the biological basis of headache transformation (Invited review).  Headache 47(8), 1251-1258.
  • L. Cao and J. A. DeLeo. 2008.  CNS infiltrating CD4+ T lymphocytes contribute to murine spinal nerve transection-induced neuropathic pain. European Journal of Immunology 38, 448-458 (featured “In This Issue”). (PMCID: PMC2963094)
  • L. Cao,  F.Y. Tanga and J. A. DeLeo. 2009.  The contributing role of CD14 in Toll-Like receptor 4 dependent neuropathic pain.  Neuroscience 158(2), 896-903. (PMCID: PMC2701510)
  • L. Cao, C. D. Palmer, J. T. Malon and J. A. DeLeo.  2009.  Critical role of microglial CD40 in the maintenance of mechanical hypersensitivityin a murine model of neuropathic pain.  European Journal of Immunology 39, 3562-3569. (PMCID: PMC2810130)
  • J. T. Malon, S. Maddula, H. Bell and L. Cao.  2012.  Involvement of calcitonin gene-related peptide and CCL2 production in CD40-mediated behavioral hypersensitivity in a model of neuropathic pain.  Neuron Glia Biology (Mar 1:1-12; published online).(PMCID: PMC4110723)
  • L. Cao, M. B. Butler, L. Tan and K. S. Draleau.  2012.  A murine immunodeficiency virus induced peripheral neuropathy and associated cytokine responses.  Journal of Immunology 189(7), 3724-33. (PMCID: PMC3448875).
  • L. Cao, H. Beaulac, and A. Eurich.  2012.  Differential lumbar spinal cord responses among wild type, CD4 knockout, and CD40 knockout mice in spinal nerve L5 transection-induced neuropathic pain. Molecular pain 8(1), 88. (PMCID: PMC3545955)
  • L. Cao and M. B. Butler.  2013.  Involvement of microglial CD40 in murine retrovirus-induced peripheral neuropathy.  Journal of Neuroimmunology 261, 37-43. (PMCID: PMC3729793)
  • K. S. Draleau, S. Maddula, A. Slaiby, N. Nutile-McMenemy, J. A. DeLeo, and L. Cao.  2014.  Phenotypic identification of spinal cord-infiltrating CD4+ T lymphocytes in a murine model of neuropathic pain.  Journal of Pain and Relief S3:003. Doi: 10.4172/2167-0846.S3-003 (PMCID: PMC4136538)
  • V. D. McLane, L. Cao, and C. L. Willis.  2014.  Morphine increases hippocampal viral load and suppresses frontal lobe cytokine expression in the LP-BM5 AIDS model.  Journal of Neuroimmunology 269(1), 44-51. (PMCID:PMC4026271)
  • J. Malon, E. Grlickova-Duzevik, J. Vaughn, T. R. Vunk, and L. Cao.  2015.  Microglial Content-Dependent Inhibitory Effects of Calcitonin Gene-Related Peptide (CGRP) on Murine Retroviral Infection of Glial Cells.  Journal of Neuroimmunology 279(1), 64-70. (PMCID: PMC4325278)
  • J. Malon and L. Cao.  2016.  Calcitonin gene-related peptide contributes to peripheral nerve injury-induced mechanical hypersensitivity through CCL5 and p38 pathways.  Journal of Neuroimmunology 297,68-75. (PMCID: PMC4940993)
  • J. Malon and L. Cao.  2016.  Preparation of primary mixed glial cultures from adult mouse spinal cord tissue.  Journal of Visulized Experiments. Nov 19;(117). doi: 10.3791/54801. (PMCID: PMC5153361)

Students

If you are interested in a research opportunity in our laboratory, please fill out the application form and submit it via email to Dr. Ling Cao.

Research interests

1. Neuroimmune mechanisms in nerve injury induced neuropathic pain and nerve regeneration

2. Neuroimmune mechanisms in HIV-associated peripheral neuropathy

3. Neuroimmune mechanisms in HIV-associated neurocognitive disorders (HANDs)

 

 

Research topics

Neuroscience
Pain
COM Faculty Research
Animal Model
Animal Studies/ Human-animal Studies
Behavioral Neuroscience
COM Immunology and Infectious Disease
COM Medical Education
COM Neuroscience and Pain

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