The Interprofessional Simulation and Innovation Center has a presence on UNE's Portland and Biddeford campuses. In Portland, it occupies part of the first floor of Innovation Hall, near the classrooms and pre-function space. In Biddeford, it has dedicated space in the Harold Alfond Forum. 

The center offers five simulation labs with adjoining fully-equipped control rooms, a task training lab and a debriefing classroom. The program also has dedicated space for staff offices, welcoming visitors, and storage. All of the labs are flexible and fully equipped for audiovisual recording, presentations, and debriefing.